Coumadin and Subcutaneous emphysema - a phase IV clinical study of FDA data

Summary:

Subcutaneous emphysema is reported as a side effect among people who take Coumadin (warfarin sodium), especially for people who are male, 50-59 old, also take Folic Acid, and have Lung cancer - non-small cell.

The phase IV clinical study analyzes which people have Subcutaneous emphysema when taking Coumadin. It is created by eHealthMe based on reports of 128,882 people who have side effects when taking Coumadin from the FDA, and is updated regularly.

What is Coumadin?

Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. eHealthMe is studying from 133,228 Coumadin users. Check the latest studies of Coumadin.

What is Subcutaneous emphysema?

Subcutaneous emphysema (smooth bulging of the skin) is found to be associated with 171 drugs and 524 conditions by eHealthMe. Check the latest studies of Subcutaneous emphysema.

On Jul, 10, 2026

128,882 people reported to have side effects when taking Coumadin.
Among them, 14 people (0.01%) have Subcutaneous emphysema.

Could Coumadin cause Subcutaneous emphysema?

Among these 14 people:

What is the gender of people who have Subcutaneous emphysema when taking Coumadin? *

female: 21.43 %
male: 78.57 %

What is the age of people who have Subcutaneous emphysema when taking Coumadin? *

What are other drugs people take besides Coumadin? *

Folic Acid: 5 people, 35.71%
Prevacid: 4 people, 28.57%
Dexamethasone: 4 people, 28.57%
Lasix: 3 people, 21.43%
Prednisone: 3 people, 21.43%
Carboplatin: 3 people, 21.43%
Lorazepam: 3 people, 21.43%
Zometa: 2 people, 14.29%
Bupropion Hydrochloride: 2 people, 14.29%
Elavil: 2 people, 14.29%

What are other side effects people have besides Subcutaneous emphysema? *

Nausea (feeling of having an urge to vomit): 6 people, 42.86%
Nausea And Vomiting: 6 people, 42.86%
Clostridial Infection (infectious conditions by clostridium bacteria): 4 people, 28.57%
Pulmonary Embolism (blockage of the main artery of the lung): 4 people, 28.57%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 4 people, 28.57%
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung): 4 people, 28.57%
Weakness: 3 people, 21.43%
Hypotension (abnormally low blood pressure): 3 people, 21.43%
Fatigue (feeling of tiredness): 3 people, 21.43%
Depression: 3 people, 21.43%

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 3 people, 21.43%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 2 people, 14.29%
Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 1 person, 7.14%
Swollen Tongue (swelling of tongue): 1 person, 7.14%
Oropharyngeal Cancer Stage Unspecified: 1 person, 7.14%
Metastases To Bone (cancer spreads to bone): 1 person, 7.14%
Insomnia (sleeplessness): 1 person, 7.14%
Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 1 person, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.14%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Coumadin and have Subcutaneous emphysema?

- Check whether Subcutaneous emphysema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Coumadin:

Coumadin (133,228 reports)

Browse all side effects of Coumadin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Subcutaneous emphysema:

Subcutaneous emphysema (171 drugs)

Browse all the conditions that are associated with Subcutaneous emphysema:

Subcutaneous emphysema (524 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on warfarin sodium (the active ingredients of Coumadin) and Coumadin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.