Cyclobenzaprine hydrochloride and Major depression - a phase IV clinical study of FDA data

Summary:

Major depression is reported as a side effect among people who take Cyclobenzaprine hydrochloride (cyclobenzaprine hydrochloride), especially for people who are male, 40-49 old, have been taking the drug for < 1 month also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Major depression when taking Cyclobenzaprine hydrochloride. It is created by eHealthMe based on reports of 7,558 people who have side effects when taking Cyclobenzaprine hydrochloride from the FDA, and is updated regularly.

What is Cyclobenzaprine hydrochloride?

Cyclobenzaprine hydrochloride has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 9,353 Cyclobenzaprine hydrochloride users. Check the latest studies of Cyclobenzaprine hydrochloride.

What is Major depression?

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings) is found to be associated with 798 drugs and 1,477 conditions by eHealthMe. Check the latest studies of Major depression.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

7,558 people reported to have side effects when taking Cyclobenzaprine hydrochloride.
Among them, 20 people (0.26%) have Major depression.

Could Cyclobenzaprine hydrochloride cause Major depression?

Among these 20 people:

How long have people been on Cyclobenzaprine hydrochloride when they have Major depression? *

What is the gender of people who have Major depression when taking Cyclobenzaprine hydrochloride? *

female: 45 %
male: 55 %

What is the age of people who have Major depression when taking Cyclobenzaprine hydrochloride? *

What are other drugs people take besides Cyclobenzaprine hydrochloride? *

Xyrem: 10 people, 50.00%
Adderall: 9 people, 45.00%
Benadryl: 8 people, 40.00%
Neurontin: 8 people, 40.00%
Zolpidem Tartrate: 8 people, 40.00%
Amitriptyline Hydrochloride: 7 people, 35.00%
Bupropion Hydrochloride: 7 people, 35.00%
Fentanyl: 7 people, 35.00%
Ondansetron: 6 people, 30.00%
Citalopram Hydrobromide: 6 people, 30.00%

What are other side effects people have besides Major depression? *

Stress And Anxiety: 10 people, 50.00%
Hypoaesthesia (reduced sense of touch or sensation): 9 people, 45.00%
Feeling Abnormal: 9 people, 45.00%
Hepatic Steatosis (fatty liver disease): 8 people, 40.00%
Pain: 8 people, 40.00%
Haematemesis (vomiting of blood): 8 people, 40.00%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 8 people, 40.00%
Burning Sensation: 8 people, 40.00%
Hypertensive Heart Disease: 8 people, 40.00%
Renal Cyst (kidney cyst): 8 people, 40.00%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 45.00%
Insomnia (sleeplessness): 8 people, 40.00%
Ill-Defined Disorder: 8 people, 40.00%
Depression: 7 people, 35.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 20.00%
Pituitary Tumor: 2 people, 10.00%
Stress And Anxiety: 1 person, 5.00%
Sleep Disorder: 1 person, 5.00%
Drowsiness: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Cyclobenzaprine hydrochloride and have Major depression?

- Check whether Major depression is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cyclobenzaprine hydrochloride:

Cyclobenzaprine hydrochloride (9,353 reports)

Major depression treatments and more:

Major depression (44,987 reports)

Browse all side effects of Cyclobenzaprine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Major depression:

Major depression (798 drugs)

Browse all the conditions that are associated with Major depression:

Major depression (1,477 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cyclobenzaprine hydrochloride (the active ingredients of Cyclobenzaprine hydrochloride) and Cyclobenzaprine hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.