Cyclophosphamide and Icterus - a phase IV clinical study of FDA data

Summary:

Icterus is reported as a side effect among people who take Cyclophosphamide (cyclophosphamide), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Methotrexate, and have Non-hodgkin's lymphoma.

The phase IV clinical study analyzes which people have Icterus when taking Cyclophosphamide. It is created by eHealthMe based on reports of 185,094 people who have side effects when taking Cyclophosphamide from the FDA, and is updated regularly.

What is Cyclophosphamide?

Cyclophosphamide has active ingredients of cyclophosphamide. It is often used in multiple myeloma. eHealthMe is studying from 185,239 Cyclophosphamide users. Check the latest studies of Cyclophosphamide.

What is Icterus?

Icterus (yellowish pigmentation of the skin) is found to be associated with 2,208 drugs and 2,985 conditions by eHealthMe. Check the latest studies of Icterus.

On Oct, 19, 2025

185,094 people reported to have side effects when taking Cyclophosphamide.
Among them, 373 people (0.2%) have Icterus.

Among these 373 people:

How long have people been on Cyclophosphamide when they have Icterus? *

What is the gender of people who have Icterus when taking Cyclophosphamide? *

female: 40.35 %
male: 59.65 %

What is the age of people who have Icterus when taking Cyclophosphamide? *

What are other drugs people take besides Cyclophosphamide? *

What are other side effects people have besides Icterus? *

Thrombocytopenia (decrease of platelets in blood): 75 people, 20.11%
Diarrhea: 60 people, 16.09%
Fever: 60 people, 16.09%
Ascites (accumulation of fluid in the abdominal cavity): 47 people, 12.60%
Hepatic Failure (liver failure): 47 people, 12.60%
Nausea (feeling of having an urge to vomit): 43 people, 11.53%
Fatigue (feeling of tiredness): 43 people, 11.53%
Rashes (redness): 42 people, 11.26%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 42 people, 11.26%
Alanine Aminotransferase Increased: 41 people, 10.99%

What are the existing conditions these people have? *

Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 53 people, 14.21%
Breast Cancer: 25 people, 6.70%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 24 people, 6.43%
High Blood Pressure: 17 people, 4.56%
Burkitt Lymphoma (cancer of the lymphatic system): 13 people, 3.49%
Thrombocytopenia (decrease of platelets in blood): 10 people, 2.68%
Bone Marrow Conditioning Regimen: 10 people, 2.68%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 9 people, 2.41%
Osteoporosis (bones weak and more likely to break): 8 people, 2.14%
Metastases To Bone (cancer spreads to bone): 7 people, 1.88%

* Approximation only. Some reports may have incomplete information.

Do you take Cyclophosphamide and have Icterus?

- Check whether Icterus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cyclophosphamide:

Cyclophosphamide (185,239 reports)

Icterus treatments and more:

Icterus (33,621 reports)

Common Cyclophosphamide side effects:

Browse all side effects of Cyclophosphamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Icterus:

Browse all the drugs that are associated with Icterus:

Icterus (2,208 drugs)

Common conditions associated with Icterus:

Hypertension aggravated: 2,055 reports
Hiv: 1,000 reports
Hiv test: 978 reports
Hepatitis c: 954 reports
Pain: 856 reports
Alternative medicine - pain relief: 832 reports
Depression: 830 reports
Dm: 676 reports
Diabetes mellitus non-insulin-dependent: 667 reports
Rheumatoid arthritis: 663 reports

Browse all the conditions that are associated with Icterus:

Icterus (2,985 conditions)

Drugs similar to Cyclophosphamide and Icterus :

Revlimid side effect: Icterus

Related publications that referenced our studies

Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .

How the study uses the data?

The study uses data from the FDA. It is based on cyclophosphamide (the active ingredients of Cyclophosphamide) and Cyclophosphamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.