Cyclophosphamide and Prothrombin time shortened - a phase IV clinical study of FDA data

Summary:

Prothrombin time shortened is reported as a side effect among people who take Cyclophosphamide (cyclophosphamide), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Fludarabine Phosphate, and have Chronic lymphocytic leukaemia.

The phase IV clinical study analyzes which people have Prothrombin time shortened when taking Cyclophosphamide. It is created by eHealthMe based on reports of 185,094 people who have side effects when taking Cyclophosphamide from the FDA, and is updated regularly.

What is Cyclophosphamide?

Cyclophosphamide has active ingredients of cyclophosphamide. It is often used in multiple myeloma. eHealthMe is studying from 185,240 Cyclophosphamide users. Check the latest studies of Cyclophosphamide.

What is Prothrombin time shortened?

Prothrombin time shortened is found to be associated with 236 drugs and 536 conditions by eHealthMe. Check the latest studies of Prothrombin time shortened.

On Aug, 07, 2026

185,094 people reported to have side effects when taking Cyclophosphamide.
Among them, 29 people (0.02%) have Prothrombin time shortened.

Could Cyclophosphamide cause Prothrombin time shortened?

Among these 29 people:

How long have people been on Cyclophosphamide when they have Prothrombin time shortened? *

What is the gender of people who have Prothrombin time shortened when taking Cyclophosphamide? *

female: 57.14 %
male: 42.86 %

What is the age of people who have Prothrombin time shortened when taking Cyclophosphamide? *

What are other drugs people take besides Cyclophosphamide? *

Acetaminophen: 5 people, 17.24%
Allopurinol: 5 people, 17.24%
Methotrexate: 5 people, 17.24%
Cyclosporine: 5 people, 17.24%
Prednisone: 5 people, 17.24%
Fludarabine Phosphate: 5 people, 17.24%
Vancomycin Hydrochloride: 4 people, 13.79%
Oncovin: 4 people, 13.79%
Prednisolone: 4 people, 13.79%
Metoprolol Tartrate: 4 people, 13.79%

What are other side effects people have besides Prothrombin time shortened? *

Thrombocytopenia (decrease of platelets in blood): 12 people, 41.38%
Blood Creatinine Increased: 9 people, 31.03%
White Blood Cell Count Decreased: 6 people, 20.69%
Fever: 6 people, 20.69%
Activated Partial Thromboplastin Time Prolonged: 5 people, 17.24%
Haemoglobin Decreased: 5 people, 17.24%
Liver Function Tests Nos Abnormal: 5 people, 17.24%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 5 people, 17.24%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 4 people, 13.79%
International Normalised Ratio Increased: 4 people, 13.79%

What are the existing conditions these people have? *

Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 6 people, 20.69%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 3 people, 10.34%
Upper Respiratory Tract Infection: 1 person, 3.45%
Oedema Peripheral (superficial swelling): 1 person, 3.45%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 3.45%
Nephrotic Syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema): 1 person, 3.45%
Nausea And Vomiting: 1 person, 3.45%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 1 person, 3.45%
Hypokalemia (low potassium): 1 person, 3.45%
Fever: 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Cyclophosphamide and have Prothrombin time shortened?

- Check whether Prothrombin time shortened is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cyclophosphamide:

Cyclophosphamide (185,240 reports)

Browse all side effects of Cyclophosphamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Prothrombin time shortened:

Prothrombin time shortened (236 drugs)

Browse all the conditions that are associated with Prothrombin time shortened:

Prothrombin time shortened (536 conditions)

Related publications that referenced our studies

Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .

How the study uses the data?

The study uses data from the FDA. It is based on cyclophosphamide (the active ingredients of Cyclophosphamide) and Cyclophosphamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.