Cyclosporine and Hyperpyrexia - a phase IV clinical study of FDA data

Summary:

Hyperpyrexia is reported as a side effect among people who take Cyclosporine (cyclosporine), especially for people who are male, 20-29 old, also take Actemra, and have Juvenile rheumatoid arthritis.

The phase IV clinical study analyzes which people have Hyperpyrexia when taking Cyclosporine. It is created by eHealthMe based on reports of 58,335 people who have side effects when taking Cyclosporine from the FDA, and is updated regularly.

What is Cyclosporine?

Cyclosporine has active ingredients of cyclosporine. It is often used in psoriasis. eHealthMe is studying from 58,714 Cyclosporine users. Check the latest studies of Cyclosporine.

What is Hyperpyrexia?

Hyperpyrexia (extremely high fever) is found to be associated with 373 drugs and 528 conditions by eHealthMe. Check the latest studies of Hyperpyrexia.

On Aug, 01, 2026

58,335 people reported to have side effects when taking Cyclosporine.
Among them, 18 people (0.03%) have Hyperpyrexia.

Among these 18 people:

What is the gender of people who have Hyperpyrexia when taking Cyclosporine? *

female: 37.5 %
male: 62.5 %

What is the age of people who have Hyperpyrexia when taking Cyclosporine? *

What are other drugs people take besides Cyclosporine? *

What are other side effects people have besides Hyperpyrexia? *

Diarrhea: 5 people, 27.78%
Dyspnea (difficult or laboured breathing): 5 people, 27.78%
Blood Creatinine Increased: 5 people, 27.78%
Lung Infection: 4 people, 22.22%
Aspartate Aminotransferase Increased: 4 people, 22.22%
Blood Lactic Acid Increased: 3 people, 16.67%
Hypotension (abnormally low blood pressure): 3 people, 16.67%
Nodule (a growth of abnormal tissue): 3 people, 16.67%
Rashes (redness): 3 people, 16.67%
Cough: 3 people, 16.67%

What are the existing conditions these people have? *

Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 4 people, 22.22%
Immunodeficiency Disorders: 3 people, 16.67%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 1 person, 5.56%
Glomerulonephritis Membranous (nephritis with inflammation of the capillary loops in the renal glomeruli): 1 person, 5.56%
Behcet's Syndrome (involves inflammation of the blood vessels): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Cyclosporine and have Hyperpyrexia?

- Check whether Hyperpyrexia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cyclosporine:

Cyclosporine (58,714 reports)

Hyperpyrexia treatments and more:

Hyperpyrexia (4,941 reports)

Browse all side effects of Cyclosporine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperpyrexia:

Hyperpyrexia (373 drugs)

Browse all the conditions that are associated with Hyperpyrexia:

Hyperpyrexia (528 conditions)

Related publications that referenced our studies

O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on cyclosporine (the active ingredients of Cyclosporine) and Cyclosporine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.