Cyclosporine and Left ventricular dysfunction - a phase IV clinical study of FDA data

Summary:

Left ventricular dysfunction is reported as a side effect among people who take Cyclosporine (cyclosporine), especially for people who are male, 40-49 old, have been taking the drug for < 1 month also take Prednisone, and have Immunodeficiency disorders.

The phase IV clinical study analyzes which people have Left ventricular dysfunction when taking Cyclosporine. It is created by eHealthMe based on reports of 58,335 people who have side effects when taking Cyclosporine from the FDA, and is updated regularly.

What is Cyclosporine?

Cyclosporine has active ingredients of cyclosporine. It is often used in psoriasis. eHealthMe is studying from 58,714 Cyclosporine users. Check the latest studies of Cyclosporine.

What is Left ventricular dysfunction?

Left ventricular dysfunction is found to be associated with 889 drugs and 792 conditions by eHealthMe. Check the latest studies of Left ventricular dysfunction.

On Jul, 24, 2026

58,335 people reported to have side effects when taking Cyclosporine.
Among them, 80 people (0.14%) have Left ventricular dysfunction.

Could Cyclosporine cause Left ventricular dysfunction?

Among these 80 people:

How long have people been on Cyclosporine when they have Left ventricular dysfunction? *

What is the gender of people who have Left ventricular dysfunction when taking Cyclosporine? *

female: 50 %
male: 50 %

What is the age of people who have Left ventricular dysfunction when taking Cyclosporine? *

What are other drugs people take besides Cyclosporine? *

Prednisone: 27 people, 33.75%
Mycophenolate Mofetil: 26 people, 32.50%
Valcyte: 14 people, 17.50%
Velcade: 11 people, 13.75%
Thalidomide: 11 people, 13.75%
Zometa: 10 people, 12.50%
Flagyl: 10 people, 12.50%
Novolog: 10 people, 12.50%
Neurontin: 10 people, 12.50%
Naloxone: 10 people, 12.50%

What are other side effects people have besides Left ventricular dysfunction? *

Acute Kidney Failure: 28 people, 35.00%
Dyspnea (difficult or laboured breathing): 24 people, 30.00%
Fatigue (feeling of tiredness): 22 people, 27.50%
Anaemia (lack of blood): 21 people, 26.25%
Fever: 19 people, 23.75%
Heart Transplant Rejection: 19 people, 23.75%
High Blood Pressure: 18 people, 22.50%
Weakness: 16 people, 20.00%
Left Ventricular Hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart): 16 people, 20.00%
Cardiac Failure: 16 people, 20.00%

What are the existing conditions these people have? *

Immunodeficiency Disorders: 15 people, 18.75%
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon): 6 people, 7.50%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 7.50%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 6 people, 7.50%
Clostridium Difficile Colitis (inflammation of colon by clostridium difficile bacteria infection): 5 people, 6.25%
Bone Marrow Conditioning Regimen: 3 people, 3.75%
Transplant Rejection (a transplant material is not worked): 3 people, 3.75%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 2 people, 2.50%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 2.50%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 2.50%

* Approximation only. Some reports may have incomplete information.

Do you take Cyclosporine and have Left ventricular dysfunction?

- Check whether Left ventricular dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cyclosporine:

Cyclosporine (58,714 reports)

Browse all side effects of Cyclosporine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Left ventricular dysfunction:

Left ventricular dysfunction (889 drugs)

Browse all the conditions that are associated with Left ventricular dysfunction:

Left ventricular dysfunction (792 conditions)

Related publications that referenced our studies

O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on cyclosporine (the active ingredients of Cyclosporine) and Cyclosporine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.