Cymbalta and Anovulatory cycle - a phase IV clinical study of FDA data

Summary:

Anovulatory cycle is reported as a side effect among people who take Cymbalta (duloxetine hydrochloride), especially for people who are 20-29 old, have been taking the drug for 1 - 6 months also take Xarelto, and have Dermatomyositis.

The phase IV clinical study analyzes which people have Anovulatory cycle when taking Cymbalta. It is created by eHealthMe based on reports of 145,249 people who have side effects when taking Cymbalta from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,973 Cymbalta users. Check the latest studies of Cymbalta.

What is Anovulatory cycle?

Anovulatory cycle (menstrual cycle during which the ovaries do not release an oocyte) is found to be associated with 23 drugs and 85 conditions by eHealthMe. Check the latest studies of Anovulatory cycle.



On Jul, 15, 2026

145,249 people reported to have side effects when taking Cymbalta.
Among them, 40 people (0.03%) have Anovulatory cycle.

Could Cymbalta cause Anovulatory cycle?

Among these 40 people:

How long have people been on Cymbalta when they have Anovulatory cycle? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the age of people who have Anovulatory cycle when taking Cymbalta? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 96.55 %
  • 30-39: 3.45 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

What are other drugs people take besides Cymbalta? *

  1. Xarelto: 38 people, 95.00%
  2. Rituxan: 21 people, 52.50%
  3. Imuran: 18 people, 45.00%
  4. Metformin: 13 people, 32.50%
  5. Plaquenil: 9 people, 22.50%
  6. Coumadin: 9 people, 22.50%
  7. Methotrexate: 6 people, 15.00%
  8. Warfarin Sodium: 5 people, 12.50%
  9. Sulfasalazine: 5 people, 12.50%
  10. Prednisone: 5 people, 12.50%

What are other side effects people have besides Anovulatory cycle? *

  1. Joint Range Of Motion Decreased (disease of joint movement): 38 people, 95.00%
  2. Malaise (a feeling of general discomfort or uneasiness): 38 people, 95.00%
  3. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 38 people, 95.00%
  4. Uterine Disorder: 38 people, 95.00%
  5. Thrombosis (formation of a blood clot inside a blood vessel): 38 people, 95.00%
  6. Haemorrhage (bleeding): 38 people, 95.00%
  7. Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 38 people, 95.00%
  8. Hepatic Enzyme Increased: 38 people, 95.00%
  9. Nausea (feeling of having an urge to vomit): 38 people, 95.00%
  10. Nasopharyngitis (inflammation of the nasopharynx): 38 people, 95.00%

What are the existing conditions these people have? *

  1. Weight Decreased: 38 people, 95.00%
  2. Pain: 38 people, 95.00%
  3. Menstrual Disorder (disease of menstrual cycle): 38 people, 95.00%
  4. Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 38 people, 95.00%
  5. Birth Control: 1 person, 2.50%

* Approximation only. Some reports may have incomplete information.

Do you take Cymbalta and have Anovulatory cycle?

- Check whether Anovulatory cycle is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cymbalta:

Anovulatory cycle treatments and more:

How severe was Anovulatory cycle and when was it recovered:

Expand to all the drugs that have ingredients of duloxetine hydrochloride:

Sub-studies by age:

0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cymbalta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anovulatory cycle:

Browse all the conditions that are associated with Anovulatory cycle:


How the study uses the data?

The study uses data from the FDA. It is based on duloxetine hydrochloride (the active ingredients of Cymbalta) and Cymbalta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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