Cymbalta and Application site papules - a phase IV clinical study of FDA data

Summary:

Application site papules is reported as a side effect among people who take Cymbalta (duloxetine hydrochloride), especially for people who are female, 60+ old, also take Zecuity, and have Headache.

The phase IV clinical study analyzes which people have Application site papules when taking Cymbalta. It is created by eHealthMe based on reports of 145,249 people who have side effects when taking Cymbalta from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,976 Cymbalta users. Check the latest studies of Cymbalta.

What is Application site papules?

Application site papules (solid elevation of skin with no visible fluid at application site) is found to be associated with 64 drugs and 148 conditions by eHealthMe. Check the latest studies of Application site papules.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

145,249 people reported to have side effects when taking Cymbalta.
Among them, 12 people (0.01%) have Application site papules.

Could Cymbalta cause Application site papules?

Among these 12 people:

What is the gender of people who have Application site papules when taking Cymbalta? *

female: 91.67 %
male: 8.33 %

What is the age of people who have Application site papules when taking Cymbalta? *

What are other drugs people take besides Cymbalta? *

What are other side effects people have besides Application site papules? *

Application Site Erythema (redness of the skin at application site): 10 people, 83.33%
Application Site Irritation: 8 people, 66.67%
Application Site Discoloration: 7 people, 58.33%
Application Site Pruritus (application site severe itching of the skin): 6 people, 50.00%
Application Site Discomfort: 6 people, 50.00%
Application Site Warmth: 6 people, 50.00%
Application Site Pain: 6 people, 50.00%
Application Site Burn: 5 people, 41.67%
Application Site Inflammation: 4 people, 33.33%
Application Site Paraesthesia (abnormal skin sensation of tingling, tickling, prickling, pricking, or burning felt at application site): 4 people, 33.33%

What are the existing conditions these people have? *

Headache (pain in head): 5 people, 41.67%
High Blood Cholesterol: 3 people, 25.00%
Migraine (headache): 2 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 16.67%
Blood Pressure Abnormal: 2 people, 16.67%
Thyroid Diseases: 1 person, 8.33%
Rosacea (a skin condition that causes facial redness): 1 person, 8.33%
Pain: 1 person, 8.33%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 1 person, 8.33%
Hot Flush (sudden feelings of heat): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Cymbalta and have Application site papules?

- Check whether Application site papules is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cymbalta:

Cymbalta (154,976 reports)

Browse all side effects of Cymbalta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site papules:

Application site papules (64 drugs)

Browse all the conditions that are associated with Application site papules:

Application site papules (148 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on duloxetine hydrochloride (the active ingredients of Cymbalta) and Cymbalta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.