Cymbalta and Bladder discomfort - a phase IV clinical study of FDA data

Summary:

Bladder discomfort is reported as a side effect among people who take Cymbalta (duloxetine hydrochloride), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Lyrica, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Bladder discomfort when taking Cymbalta. It is created by eHealthMe based on reports of 145,249 people who have side effects when taking Cymbalta from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,974 Cymbalta users. Check the latest studies of Cymbalta.

What is Bladder discomfort?

Bladder discomfort is found to be associated with 206 drugs and 305 conditions by eHealthMe. Check the latest studies of Bladder discomfort.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

145,249 people reported to have side effects when taking Cymbalta.
Among them, 21 people (0.01%) have Bladder discomfort.

Could Cymbalta cause Bladder discomfort?

Among these 21 people:

How long have people been on Cymbalta when they have Bladder discomfort? *

What is the gender of people who have Bladder discomfort when taking Cymbalta? *

female: 77.78 %
male: 22.22 %

What is the age of people who have Bladder discomfort when taking Cymbalta? *

What are other drugs people take besides Cymbalta? *

What are other side effects people have besides Bladder discomfort? *

Headache (pain in head): 9 people, 42.86%
Nausea (feeling of having an urge to vomit): 9 people, 42.86%
Pain In Extremity: 8 people, 38.10%
Fatigue (feeling of tiredness): 7 people, 33.33%
Pain: 7 people, 33.33%
Gait Disturbance: 7 people, 33.33%
Diarrhea: 7 people, 33.33%
Joint Pain: 7 people, 33.33%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 6 people, 28.57%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 6 people, 28.57%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 19.05%
Pain: 3 people, 14.29%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 14.29%
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other): 2 people, 9.52%
Osteoporosis (bones weak and more likely to break): 2 people, 9.52%
Bladder Disorder: 2 people, 9.52%
Panic Disorder: 1 person, 4.76%
Gastrointestinal Pain: 1 person, 4.76%
Blood Urine Present: 1 person, 4.76%
Breast Cancer: 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Cymbalta and have Bladder discomfort?

- Check whether Bladder discomfort is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cymbalta:

Cymbalta (154,974 reports)

Browse all side effects of Cymbalta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bladder discomfort:

Bladder discomfort (206 drugs)

Browse all the conditions that are associated with Bladder discomfort:

Bladder discomfort (305 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on duloxetine hydrochloride (the active ingredients of Cymbalta) and Cymbalta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.