Cymbalta and Cachexia - a phase IV clinical study of FDA data

Summary:

Cachexia is reported as a side effect among people who take Cymbalta (duloxetine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Zoloft, and have Connective tissue disorder.

The phase IV clinical study analyzes which people have Cachexia when taking Cymbalta. It is created by eHealthMe based on reports of 145,249 people who have side effects when taking Cymbalta from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,972 Cymbalta users. Check the latest studies of Cymbalta.

What is Cachexia?

Cachexia (loss of weight) is found to be associated with 666 drugs and 1,201 conditions by eHealthMe. Check the latest studies of Cachexia.

On Jun, 14, 2026

145,249 people reported to have side effects when taking Cymbalta.
Among them, 18 people (0.01%) have Cachexia.

Among these 18 people:

How long have people been on Cymbalta when they have Cachexia? *

What is the gender of people who have Cachexia when taking Cymbalta? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Cachexia when taking Cymbalta? *

What are other drugs people take besides Cymbalta? *

What are other side effects people have besides Cachexia? *

Weight Decreased: 12 people, 66.67%
Diarrhea: 11 people, 61.11%
Malaise (a feeling of general discomfort or uneasiness): 11 people, 61.11%
Nausea (feeling of having an urge to vomit): 11 people, 61.11%
Weakness: 9 people, 50.00%
Fatigue (feeling of tiredness): 9 people, 50.00%
Dizziness: 9 people, 50.00%
Hyperhidrosis (abnormally increased sweating): 8 people, 44.44%
Nausea And Vomiting: 8 people, 44.44%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 8 people, 44.44%

What are the existing conditions these people have? *

Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 3 people, 16.67%
Pain: 3 people, 16.67%
Myositis (inflammation of the muscles): 3 people, 16.67%
Muscle Aches (muscle pain): 3 people, 16.67%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 3 people, 16.67%
Headache (pain in head): 3 people, 16.67%
Connective Tissue Disorder (any disease that has the connective tissues of the body): 3 people, 16.67%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 11.11%
Neuroendocrine Tumor: 2 people, 11.11%
Nausea (feeling of having an urge to vomit): 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Cymbalta and have Cachexia?

- Check whether Cachexia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cymbalta:

Cymbalta (154,972 reports)

Cachexia treatments and more:

Cachexia (7,763 reports)

Browse all side effects of Cymbalta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cachexia:

Cachexia (666 drugs)

Browse all the conditions that are associated with Cachexia:

Cachexia (1,201 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on duloxetine hydrochloride (the active ingredients of Cymbalta) and Cymbalta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.