Cymbalta and Drug tolerance decreased - a phase IV clinical study of FDA data

Summary:

Drug tolerance decreased is reported as a side effect among people who take Cymbalta (duloxetine hydrochloride), especially for people who are female, 50-59 old, also take Plaquenil, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Drug tolerance decreased when taking Cymbalta. It is created by eHealthMe based on reports of 145,249 people who have side effects when taking Cymbalta from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,973 Cymbalta users. Check the latest studies of Cymbalta.

What is Drug tolerance decreased?

Drug tolerance decreased is found to be associated with 314 drugs and 375 conditions by eHealthMe. Check the latest studies of Drug tolerance decreased.

On Jul, 04, 2026

145,249 people reported to have side effects when taking Cymbalta.
Among them, 25 people (0.02%) have Drug tolerance decreased.

Could Cymbalta cause Drug tolerance decreased?

Among these 25 people:

What is the gender of people who have Drug tolerance decreased when taking Cymbalta? *

female: 80 %
male: 20 %

What is the age of people who have Drug tolerance decreased when taking Cymbalta? *

What are other drugs people take besides Cymbalta? *

What are other side effects people have besides Drug tolerance decreased? *

Pain: 9 people, 36.00%
Headache (pain in head): 9 people, 36.00%
Nausea (feeling of having an urge to vomit): 9 people, 36.00%
Drug Ineffective: 9 people, 36.00%
Nausea And Vomiting: 8 people, 32.00%
Mood Swings (an extreme or rapid change in mood): 8 people, 32.00%
Aspartate Aminotransferase Increased: 7 people, 28.00%
Limb Deformity (functional disability of leg): 7 people, 28.00%
Nasopharyngitis (inflammation of the nasopharynx): 7 people, 28.00%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 7 people, 28.00%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 28.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 20.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 8.00%
Rashes (redness): 2 people, 8.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 8.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 8.00%
Pain: 2 people, 8.00%
Back Pain: 1 person, 4.00%
Breakthrough Pain: 1 person, 4.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Cymbalta and have Drug tolerance decreased?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cymbalta:

Cymbalta (154,973 reports)

Browse all side effects of Cymbalta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Drug tolerance decreased:

Drug tolerance decreased (314 drugs)

Browse all the conditions that are associated with Drug tolerance decreased:

Drug tolerance decreased (375 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on duloxetine hydrochloride (the active ingredients of Cymbalta) and Cymbalta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.