Cymbalta and Hyperpyrexia - a phase IV clinical study of FDA data

Summary:

Hyperpyrexia is reported as a side effect among people who take Cymbalta (duloxetine hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Lyrica, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Hyperpyrexia when taking Cymbalta. It is created by eHealthMe based on reports of 145,249 people who have side effects when taking Cymbalta from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,976 Cymbalta users. Check the latest studies of Cymbalta.

What is Hyperpyrexia?

Hyperpyrexia (extremely high fever) is found to be associated with 368 drugs and 530 conditions by eHealthMe. Check the latest studies of Hyperpyrexia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

145,249 people reported to have side effects when taking Cymbalta.
Among them, 17 people (0.01%) have Hyperpyrexia.

Among these 17 people:

How long have people been on Cymbalta when they have Hyperpyrexia? *

What is the gender of people who have Hyperpyrexia when taking Cymbalta? *

female: 21.43 %
male: 78.57 %

What is the age of people who have Hyperpyrexia when taking Cymbalta? *

What are other drugs people take besides Cymbalta? *

What are other side effects people have besides Hyperpyrexia? *

Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases): 14 people, 82.35%
Confusional State: 14 people, 82.35%
Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain): 14 people, 82.35%
Acute Kidney Failure: 2 people, 11.76%
Hypotension (abnormally low blood pressure): 2 people, 11.76%
Pain: 2 people, 11.76%
Bacterial Infection: 1 person, 5.88%
Azotaemia (excess of urea or other nitrogenous compounds in the blood): 1 person, 5.88%
Gangrene (body tissue dies): 1 person, 5.88%
Flatulence (flatus expelled through the anus): 1 person, 5.88%

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.88%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.88%
Pain: 1 person, 5.88%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 5.88%
Cardiac Failure Chronic: 1 person, 5.88%
Cardiac Failure: 1 person, 5.88%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Cymbalta and have Hyperpyrexia?

- Check whether Hyperpyrexia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cymbalta:

Cymbalta (154,976 reports)

Hyperpyrexia treatments and more:

Hyperpyrexia (4,941 reports)

Browse all side effects of Cymbalta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperpyrexia:

Hyperpyrexia (368 drugs)

Browse all the conditions that are associated with Hyperpyrexia:

Hyperpyrexia (530 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on duloxetine hydrochloride (the active ingredients of Cymbalta) and Cymbalta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.