Cymbalta and Hypertonia - a phase IV clinical study of FDA data

Summary:

Hypertonia is reported as a side effect among people who take Cymbalta (duloxetine hydrochloride), especially for people who are male, 20-29 old, have been taking the drug for < 1 month also take Valium, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Hypertonia when taking Cymbalta. It is created by eHealthMe based on reports of 145,249 people who have side effects when taking Cymbalta from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,973 Cymbalta users. Check the latest studies of Cymbalta.

What is Hypertonia?

Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch) is found to be associated with 491 drugs and 692 conditions by eHealthMe. Check the latest studies of Hypertonia.

On Jul, 14, 2026

145,249 people reported to have side effects when taking Cymbalta.
Among them, 57 people (0.04%) have Hypertonia.

Among these 57 people:

How long have people been on Cymbalta when they have Hypertonia? *

What is the gender of people who have Hypertonia when taking Cymbalta? *

female: 47.17 %
male: 52.83 %

What is the age of people who have Hypertonia when taking Cymbalta? *

What are other drugs people take besides Cymbalta? *

What are other side effects people have besides Hypertonia? *

Tremor (trembling or shaking movements in one or more parts of your body): 23 people, 40.35%
Hypotension (abnormally low blood pressure): 12 people, 21.05%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 12 people, 21.05%
High Blood Pressure: 10 people, 17.54%
Reflexes Abnormal (body receives a certain stimulus not normally): 9 people, 15.79%
Agitation (state of anxiety or nervous excitement): 9 people, 15.79%
Bundle Branch Block Right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle): 9 people, 15.79%
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions): 9 people, 15.79%
Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 9 people, 15.79%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 9 people, 15.79%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 10.53%
Insomnia (sleeplessness): 4 people, 7.02%
Pain: 4 people, 7.02%
Sedation: 4 people, 7.02%
Bipolar Disorder (mood disorder): 3 people, 5.26%
Pain In Extremity: 3 people, 5.26%
Urinary Tract Infection: 3 people, 5.26%
Neuralgia (pain in one or more nerves): 3 people, 5.26%
Sleep Disorder: 3 people, 5.26%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 2 people, 3.51%

* Approximation only. Some reports may have incomplete information.

Do you take Cymbalta and have Hypertonia?

- Check whether Hypertonia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cymbalta:

Cymbalta (154,973 reports)

Hypertonia treatments and more:

Hypertonia (11,073 reports)

Browse all side effects of Cymbalta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypertonia:

Hypertonia (491 drugs)

Browse all the conditions that are associated with Hypertonia:

Hypertonia (692 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on duloxetine hydrochloride (the active ingredients of Cymbalta) and Cymbalta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.