Cymbalta and Macular hole - a phase IV clinical study of FDA data

Summary:

Macular hole is reported as a side effect among people who take Cymbalta (duloxetine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Oxycodone, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Macular hole when taking Cymbalta. It is created by eHealthMe based on reports of 145,249 people who have side effects when taking Cymbalta from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,972 Cymbalta users. Check the latest studies of Cymbalta.

What is Macular hole?

Macular hole (small break in the macula, the central area of the retina) is found to be associated with 178 drugs and 525 conditions by eHealthMe. Check the latest studies of Macular hole.

On Jun, 13, 2026

145,249 people reported to have side effects when taking Cymbalta.
Among them, 18 people (0.01%) have Macular hole.

Among these 18 people:

How long have people been on Cymbalta when they have Macular hole? *

What is the gender of people who have Macular hole when taking Cymbalta? *

female: 94.12 %
male: 5.88 %

What is the age of people who have Macular hole when taking Cymbalta? *

What are other drugs people take besides Cymbalta? *

Xeljanz: 5 people, 27.78%
Oxycodone: 5 people, 27.78%
Hydroxychloroquine Sulfate: 4 people, 22.22%
Xywav: 3 people, 16.67%
Scopolamine: 3 people, 16.67%
Betamethasone Dipropionate: 3 people, 16.67%
Diclofenac Sodium: 3 people, 16.67%
Flonase: 3 people, 16.67%
Furosemide: 3 people, 16.67%
Imitrex: 3 people, 16.67%

What are other side effects people have besides Macular hole? *

Fall: 6 people, 33.33%
Urinary Tract Infection: 6 people, 33.33%
Delirium (wild excitement): 5 people, 27.78%
Fever: 5 people, 27.78%
Fungal Infection: 5 people, 27.78%
Rib Fracture: 5 people, 27.78%
Chronic Kidney Disease: 3 people, 16.67%
Head Injury: 3 people, 16.67%
Lung Infection: 3 people, 16.67%
Tinnitus (a ringing in the ears): 3 people, 16.67%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 33.33%
Drowsiness: 3 people, 16.67%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 2 people, 11.11%
Vitamin B Complex Deficiency: 1 person, 5.56%
Rickets (softening of bones): 1 person, 5.56%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 5.56%
Pancreatitis (inflammation of pancreas): 1 person, 5.56%
Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 5.56%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 5.56%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Cymbalta and have Macular hole?

- Check whether Macular hole is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cymbalta:

Cymbalta (154,972 reports)

Macular hole treatments and more:

Macular hole (1,673 reports)

Browse all side effects of Cymbalta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Macular hole:

Macular hole (178 drugs)

Browse all the conditions that are associated with Macular hole:

Macular hole (525 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on duloxetine hydrochloride (the active ingredients of Cymbalta) and Cymbalta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.