Cymbalta and Optic neuropathy - a phase IV clinical study of FDA data

Summary:

Optic neuropathy is reported as a side effect among people who take Cymbalta (duloxetine hydrochloride), especially for people who are female, 60+ old, also take Cordarone, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Optic neuropathy when taking Cymbalta. It is created by eHealthMe based on reports of 145,249 people who have side effects when taking Cymbalta from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,973 Cymbalta users. Check the latest studies of Cymbalta.

What is Optic neuropathy?

Optic neuropathy (optic nerve damage) is found to be associated with 258 drugs and 451 conditions by eHealthMe. Check the latest studies of Optic neuropathy.

On Jul, 21, 2026

145,249 people reported to have side effects when taking Cymbalta.
Among them, 24 people (0.02%) have Optic neuropathy.

Among these 24 people:

What is the gender of people who have Optic neuropathy when taking Cymbalta? *

female: 91.67 %
male: 8.33 %

What is the age of people who have Optic neuropathy when taking Cymbalta? *

What are other drugs people take besides Cymbalta? *

What are other side effects people have besides Optic neuropathy? *

Visual Acuity Reduced (reduced clearness of vision): 19 people, 79.17%
Dyspnea (difficult or laboured breathing): 18 people, 75.00%
Pneumonia: 16 people, 66.67%
Cerebellar Syndrome (impaired blood circulation to cerebellum due to lesion in artery): 16 people, 66.67%
Neuropathy Peripheral (surface nerve damage): 16 people, 66.67%
Optic Atrophy (the loss of a proportion of optic disc nerve fibres): 16 people, 66.67%
Eye Haemorrhage (bleeding in the eye): 16 people, 66.67%
Optic Neuritis (optic nerve inflammation): 16 people, 66.67%
Cardiac Failure: 16 people, 66.67%
Papilloedema (optic disc swelling): 16 people, 66.67%

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 14 people, 58.33%
Oedema (fluid collection in tissue): 6 people, 25.00%
Cardiac Failure: 5 people, 20.83%
Affective Disorder (mental disorder): 2 people, 8.33%
Sleep Disorder: 2 people, 8.33%
Post-Traumatic Stress Disorder: 2 people, 8.33%
Pain: 2 people, 8.33%
Neuralgia (pain in one or more nerves): 2 people, 8.33%
Tremor (trembling or shaking movements in one or more parts of your body): 2 people, 8.33%
Depressive Symptom: 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Cymbalta and have Optic neuropathy?

- Check whether Optic neuropathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cymbalta:

Cymbalta (154,973 reports)

Browse all side effects of Cymbalta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Optic neuropathy:

Optic neuropathy (258 drugs)

Browse all the conditions that are associated with Optic neuropathy:

Optic neuropathy (451 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on duloxetine hydrochloride (the active ingredients of Cymbalta) and Cymbalta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.