Cymbalta and Rectal prolapse - a phase IV clinical study of FDA data

Summary:

Rectal prolapse is reported as a side effect among people who take Cymbalta (duloxetine hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years also take Abilify, and have High blood pressure.

The phase IV clinical study analyzes which people have Rectal prolapse when taking Cymbalta. It is created by eHealthMe based on reports of 145,249 people who have side effects when taking Cymbalta from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,974 Cymbalta users. Check the latest studies of Cymbalta.

What is Rectal prolapse?

Rectal prolapse (falling of rectum from normal place) is found to be associated with 307 drugs and 341 conditions by eHealthMe. Check the latest studies of Rectal prolapse.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

145,249 people reported to have side effects when taking Cymbalta.
Among them, 51 people (0.04%) have Rectal prolapse.

Among these 51 people:

How long have people been on Cymbalta when they have Rectal prolapse? *

What is the gender of people who have Rectal prolapse when taking Cymbalta? *

female: 100 %
male: 0.0 %

What is the age of people who have Rectal prolapse when taking Cymbalta? *

What are other drugs people take besides Cymbalta? *

What are other side effects people have besides Rectal prolapse? *

Fatigue (feeling of tiredness): 24 people, 47.06%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 18 people, 35.29%
Swelling Face: 17 people, 33.33%
Muscle Aches (muscle pain): 16 people, 31.37%
Bone Disorder: 15 people, 29.41%
Constipation: 15 people, 29.41%
Rectal Haemorrhage (bleeding from anus): 15 people, 29.41%
Joint Pain: 14 people, 27.45%
Migraine (headache): 13 people, 25.49%
Arrhythmias (irregular heartbeat): 13 people, 25.49%

What are the existing conditions these people have? *

High Blood Pressure: 14 people, 27.45%
Pain: 13 people, 25.49%
Allergic Rhinitis: 11 people, 21.57%
Migraine (headache): 11 people, 21.57%
Sleep Apnea Syndrome: 11 people, 21.57%
Rickets (softening of bones): 11 people, 21.57%
Headache (pain in head): 11 people, 21.57%
Hypokalemia (low potassium): 11 people, 21.57%
Sleep Disorder: 11 people, 21.57%
Immunodeficiency Common Variable: 6 people, 11.76%

* Approximation only. Some reports may have incomplete information.

Do you take Cymbalta and have Rectal prolapse?

- Check whether Rectal prolapse is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cymbalta:

Cymbalta (154,974 reports)

Rectal prolapse treatments and more:

Rectal prolapse (1,711 reports)

Browse all side effects of Cymbalta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Rectal prolapse:

Rectal prolapse (307 drugs)

Browse all the conditions that are associated with Rectal prolapse:

Rectal prolapse (341 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on duloxetine hydrochloride (the active ingredients of Cymbalta) and Cymbalta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.