Cytotec and Limb reduction defect - a phase IV clinical study of FDA data

Summary:

Limb reduction defect is reported as a side effect among people who take Cytotec (misoprostol), especially for people who are female, 0-1 old, have been taking the drug for < 1 month also take Paracetamol, and have Abortion induced.

The phase IV clinical study analyzes which people have Limb reduction defect when taking Cytotec. It is created by eHealthMe based on reports of 5,765 people who have side effects when taking Cytotec from the FDA, and is updated regularly.

What is Cytotec?

Cytotec has active ingredients of misoprostol. It is often used in abortion. eHealthMe is studying from 5,812 Cytotec users. Check the latest studies of Cytotec.

What is Limb reduction defect?

Limb reduction defect (a birth defect in which all or some of the limbs of a foetus do not completely form while in utero) is found to be associated with 62 drugs and 134 conditions by eHealthMe. Check the latest studies of Limb reduction defect.

On Aug, 09, 2026

5,765 people reported to have side effects when taking Cytotec.
Among them, 12 people (0.21%) have Limb reduction defect.

Could Cytotec cause Limb reduction defect?

Among these 12 people:

How long have people been on Cytotec when they have Limb reduction defect? *

What is the gender of people who have Limb reduction defect when taking Cytotec? *

female: 100 %
male: 0.0 %

What is the age of people who have Limb reduction defect when taking Cytotec? *

What are other drugs people take besides Cytotec? *

Promethazine: 9 people, 75.00%
Paracetamol: 9 people, 75.00%
Laminaria: 1 person, 8.33%
Atripla: 1 person, 8.33%

What are other side effects people have besides Limb reduction defect? *

Exomphalos (weakness of the baby's abdominal wall where the umbilical cord joins it): 9 people, 75.00%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 5 people, 41.67%
Limb Hypoplasia Congenital (incomplete developed limb): 1 person, 8.33%
Intra-Uterine Death: 1 person, 8.33%
Foetal Malformation (birth defect abnormal or anomalous formation or structure): 1 person, 8.33%
Encephalocele (hernia of the brain that is either congenital or due to trauma): 1 person, 8.33%
Dysmorphism (difference of body structure that is suggestive of a congenital disorder): 1 person, 8.33%
Drug Exposure During Pregnancy: 1 person, 8.33%

What are the existing conditions these people have? *

Rickets (softening of bones): 8 people, 66.67%
Headache (pain in head): 8 people, 66.67%
Depression: 8 people, 66.67%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 8 people, 66.67%
Agitation (state of anxiety or nervous excitement): 8 people, 66.67%
Abortion Induced (medically referred abortion): 8 people, 66.67%
Hiv Infection: 1 person, 8.33%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Cytotec and have Limb reduction defect?

- Check whether Limb reduction defect is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cytotec:

Cytotec (5,812 reports)

Browse all side effects of Cytotec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Limb reduction defect:

Limb reduction defect (62 drugs)

Browse all the conditions that are associated with Limb reduction defect:

Limb reduction defect (134 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on misoprostol (the active ingredients of Cytotec) and Cytotec (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.