Cytotec and Raynaud's phenomenon - a phase IV clinical study of FDA data

Summary:

Raynaud's phenomenon is reported as a side effect among people who take Cytotec (misoprostol), especially for people who are male, 60+ old, have been taking the drug for 10+ years also take Methotrexate, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Raynaud's phenomenon when taking Cytotec. It is created by eHealthMe based on reports of 5,765 people who have side effects when taking Cytotec from the FDA, and is updated regularly.

What is Cytotec?

Cytotec has active ingredients of misoprostol. It is often used in abortion. eHealthMe is studying from 5,812 Cytotec users. Check the latest studies of Cytotec.

What is Raynaud's phenomenon?

Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas) is found to be associated with 626 drugs and 997 conditions by eHealthMe. Check the latest studies of Raynaud's phenomenon.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

5,765 people reported to have side effects when taking Cytotec.
Among them, 31 people (0.54%) have Raynaud's phenomenon.

Could Cytotec cause Raynaud's phenomenon?

Among these 31 people:

How long have people been on Cytotec when they have Raynaud's phenomenon? *

What is the gender of people who have Raynaud's phenomenon when taking Cytotec? *

female: 22.58 %
male: 77.42 %

What is the age of people who have Raynaud's phenomenon when taking Cytotec? *

What are other drugs people take besides Cytotec? *

Folic Acid: 26 people, 83.87%
Methotrexate: 26 people, 83.87%
Lipitor: 24 people, 77.42%
Avapro: 24 people, 77.42%
Ciprofloxacin Hydrochloride: 24 people, 77.42%
Enbrel: 24 people, 77.42%
Felodipine: 24 people, 77.42%
Omeprazole: 24 people, 77.42%
Naproxen: 24 people, 77.42%
Latuda: 23 people, 74.19%

What are other side effects people have besides Raynaud's phenomenon? *

Pain In Extremity: 26 people, 83.87%
Fall: 25 people, 80.65%
C-Reactive Protein Increased: 25 people, 80.65%
Inflammation: 25 people, 80.65%
Skin Discoloration: 25 people, 80.65%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 25 people, 80.65%
Joint Pain: 24 people, 77.42%
Night Sweats (sweating in night): 24 people, 77.42%
Dry Skin: 24 people, 77.42%
Nail Bed Bleeding: 24 people, 77.42%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 28 people, 90.32%
Tendonitis (a condition that causes pain and swelling of tendons): 1 person, 3.23%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Cytotec and have Raynaud's phenomenon?

- Check whether Raynaud's phenomenon is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cytotec:

Cytotec (5,812 reports)

Browse all side effects of Cytotec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Raynaud's phenomenon:

Raynaud's phenomenon (626 drugs)

Browse all the conditions that are associated with Raynaud's phenomenon:

Raynaud's phenomenon (997 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on misoprostol (the active ingredients of Cytotec) and Cytotec (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.