Dacarbazine and Gastrointestinal toxicity - a phase IV clinical study of FDA data

Summary:

Gastrointestinal toxicity is reported as a side effect among people who take Dacarbazine (dacarbazine), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Emend, and have Hodgkin's lymphoma.

The phase IV clinical study analyzes which people have Gastrointestinal toxicity when taking Dacarbazine. It is created by eHealthMe based on reports of 8,052 people who have side effects when taking Dacarbazine from the FDA, and is updated regularly.

What is Dacarbazine?

Dacarbazine has active ingredients of dacarbazine. eHealthMe is studying from 8,064 Dacarbazine users. Check the latest studies of Dacarbazine.

What is Gastrointestinal toxicity?

Gastrointestinal toxicity (damage to digestive tract by any substance) is found to be associated with 308 drugs and 343 conditions by eHealthMe. Check the latest studies of Gastrointestinal toxicity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

8,052 people reported to have side effects when taking Dacarbazine.
Among them, 15 people (0.19%) have Gastrointestinal toxicity.

Could Dacarbazine cause Gastrointestinal toxicity?

Among these 15 people:

How long have people been on Dacarbazine when they have Gastrointestinal toxicity? *

What is the gender of people who have Gastrointestinal toxicity when taking Dacarbazine? *

female: 85.71 %
male: 14.29 %

What is the age of people who have Gastrointestinal toxicity when taking Dacarbazine? *

What are other drugs people take besides Dacarbazine? *

Innohep: 2 people, 13.33%
Humatin: 2 people, 13.33%
Bortezomib: 2 people, 13.33%
Doxorubicin Hydrochloride: 2 people, 13.33%
Emend: 2 people, 13.33%
Bleomycin Sulfate: 1 person, 6.67%
Dexamethasone: 1 person, 6.67%
Escitalopram: 1 person, 6.67%
Vinblastine Sulfate: 1 person, 6.67%
Valacyclovir: 1 person, 6.67%

What are other side effects people have besides Gastrointestinal toxicity? *

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 6 people, 40.00%
Infection: 6 people, 40.00%
Haematotoxicity (toxins that destroy red blood cells): 5 people, 33.33%
Thrombocytopenia (decrease of platelets in blood): 5 people, 33.33%
Nausea And Vomiting: 4 people, 26.67%
Leukopenia (less number of white blood cells in blood): 4 people, 26.67%
Cardiotoxicity (damage to the heart muscle): 4 people, 26.67%
Diarrhea: 4 people, 26.67%
Febrile Neutropenia (fever with reduced white blood cells): 4 people, 26.67%
Nausea (feeling of having an urge to vomit): 4 people, 26.67%

What are the existing conditions these people have? *

Hodgkin's Lymphoma (cancer originating from white blood cells): 7 people, 46.67%
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 2 people, 13.33%
Lymphoma (cancer that begins in immune system cells): 2 people, 13.33%
Waldenstrom's Macroglobulinaemia (cancer affects small lymphocytes (white blood cells)): 1 person, 6.67%
Stress And Anxiety: 1 person, 6.67%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 1 person, 6.67%
Malignant Melanoma (skin cancer rises from melancytes): 1 person, 6.67%
Hiv Infection: 1 person, 6.67%
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble): 1 person, 6.67%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Dacarbazine and have Gastrointestinal toxicity?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dacarbazine:

Dacarbazine (8,064 reports)

Browse all side effects of Dacarbazine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gastrointestinal toxicity:

Gastrointestinal toxicity (308 drugs)

Browse all the conditions that are associated with Gastrointestinal toxicity:

Gastrointestinal toxicity (343 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dacarbazine (the active ingredients of Dacarbazine) and Dacarbazine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.