Dactinomycin and Death sudden - a phase IV clinical study of FDA data

Summary:

Death sudden is reported as a side effect among people who take Dactinomycin (dactinomycin), especially for people who are female, 2-9 old, have been taking the drug for 6 - 12 months also take Cyclophosphamide, and have Ewing's sarcoma.

The study is created by eHealthMe based on reports of 2,575 people who have side effects when taking Dactinomycin from the FDA, and is updated regularly.

What is Dactinomycin?

Dactinomycin has active ingredients of dactinomycin. eHealthMe is studying from 2,577 Dactinomycin users. Check the latest studies of Dactinomycin.

On Jun, 17, 2026

2,575 people reported to have side effects when taking Dactinomycin.
Among them, 33 people (1.28%) died.

Among these 33 people:

How long have people been on Dactinomycin when they died? *

What is the gender of people who died when taking Dactinomycin? *

female: 57.14 %
male: 42.86 %

What is the age of people who died when taking Dactinomycin? *

What are other drugs people take besides Dactinomycin? *

Cyclophosphamide: 18 people, 54.55%
Etoposide: 10 people, 30.30%
Mesna: 6 people, 18.18%
Doxorubicin Hydrochloride: 6 people, 18.18%
Ifosfamide: 5 people, 15.15%
Vincristine Sulfate: 5 people, 15.15%
Temsirolimus: 3 people, 9.09%
Camptosar: 3 people, 9.09%
Heparin: 2 people, 6.06%
Lorazepam: 2 people, 6.06%

What are other side effects people have before they died? *

Nausea And Vomiting: 3 people, 9.09%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 2 people, 6.06%
Thrombocytopenia (decrease of platelets in blood): 2 people, 6.06%
Stomatitis (inflammation of mucous membrane of mouth): 2 people, 6.06%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 2 people, 6.06%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 2 people, 6.06%
Disease Progression: 2 people, 6.06%
Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 2 people, 6.06%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 2 people, 6.06%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 6.06%

What are the existing conditions these people have? *

Ewing's Sarcoma (malignant small, round, blue cell tumour): 8 people, 24.24%
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 6 people, 18.18%
Wilms Tumor (cancer of the kidneys that typically occurs in children): 3 people, 9.09%
Metastases To Lung (cancer spreads to lung): 1 person, 3.03%
Adrenocortical Carcinoma (adrenal cortex cancer): 1 person, 3.03%
Bone Pain: 1 person, 3.03%
Gestational Trophoblastic Disease (disease of foetus surrounding during pregnancy): 1 person, 3.03%
Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 3.03%
Malignant Hydatidiform Mole (a cancer tumour of trophoblast cells): 1 person, 3.03%
Metastases To Central Nervous System (cancer spreads to central nervous system): 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dactinomycin:

Dactinomycin (2,577 reports)

Expand to all the drugs that have ingredients of dactinomycin:

Death sudden and drugs with ingredients of dactinomycin (46 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Dactinomycin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Death sudden:

Death sudden (3,717 drugs)

Browse all the conditions that are associated with Death sudden:

Death sudden (3,741 conditions)

Related publications that referenced our studies

Dong H, Zhang J, Ren L, Liu Q, Zhu S, "Unexpected death due to cefuroxime-induced disulfiram-like reaction", Indian journal of pharmacology, 2013 Jan .
Dong H, Zhang J, Ren L, Liu Q, Zhu S, "Unexpected death due to cefuroxime-induced disulfiram-like reaction", Indian journal of pharmacology, 2013 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on dactinomycin (the active ingredients of Dactinomycin) and Dactinomycin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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