Daptomycin and C. difficile - a phase IV clinical study of FDA data

Summary:

C. difficile is reported as a side effect among people who take Daptomycin (daptomycin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vancomycin, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have C. difficile when taking Daptomycin. It is created by eHealthMe based on reports of 7,865 people who have side effects when taking Daptomycin from the FDA, and is updated regularly.

What is Daptomycin?

Daptomycin has active ingredients of daptomycin. eHealthMe is studying from 7,879 Daptomycin users. Check the latest studies of Daptomycin.

What is C. difficile?

C. difficile is found to be associated with 1,819 drugs and 1,784 conditions by eHealthMe. Check the latest studies of C. difficile.

On Jun, 18, 2026

7,865 people reported to have side effects when taking Daptomycin.
Among them, 24 people (0.31%) have C. difficile.

Among these 24 people:

How long have people been on Daptomycin when they have C. difficile? *

What is the gender of people who have C. difficile when taking Daptomycin? *

female: 54.55 %
male: 45.45 %

What is the age of people who have C. difficile when taking Daptomycin? *

What are other drugs people take besides Daptomycin? *

What are other side effects people have besides C. difficile? *

Drug Ineffective: 7 people, 29.17%
Thrombocytopenia (decrease of platelets in blood): 6 people, 25.00%
Staphylococcal Infection (an infection with staphylococcus bacteria): 6 people, 25.00%
High Blood Pressure: 5 people, 20.83%
Chronic Renal Failure (kidney failure): 4 people, 16.67%
Depression: 4 people, 16.67%
Oedema Peripheral (superficial swelling): 4 people, 16.67%
Chest Pain: 4 people, 16.67%
Cellulitis (infection under the skin): 4 people, 16.67%
Cardiac Failure Congestive: 4 people, 16.67%

What are the existing conditions these people have? *

Abdominal Infection: 7 people, 29.17%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 29.17%
Urinary Tract Infection: 3 people, 12.50%
Back Pain: 3 people, 12.50%
Cellulitis (infection under the skin): 3 people, 12.50%
Multiple Myeloma (cancer of the plasma cells): 3 people, 12.50%
Osteomyelitis Bacterial (infection of bone by bacteria): 2 people, 8.33%
Beta Haemolytic Streptococcal Infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue): 2 people, 8.33%
Immunodeficiency Disorders: 2 people, 8.33%
Depression: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Daptomycin and have C. difficile?

- Check whether C. difficile is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Daptomycin:

Daptomycin (7,879 reports)

C. difficile treatments and more:

C. difficile (13,845 reports)

Browse all side effects of Daptomycin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with C. difficile:

C. difficile (1,819 drugs)

Browse all the conditions that are associated with C. difficile:

C. difficile (1,784 conditions)

Related publications that referenced our studies

Saliho?lu M, Turhan V, ?nem Y, Ulcay A, Uzun G, Ay H, "Sudden hearing loss in a patient receiving piperacillin/tazobactam and daptomycin for diabetic foot infection", Scandinavian journal of infectious diseases, 2013 Mar .
Saliho?lu M, Turhan V, ?nem Y, Ulcay A, Uzun G, Ay H, "Sudden hearing loss in a patient receiving piperacillin/tazobactam and daptomycin for diabetic foot infection", Scandinavian journal of infectious diseases, 2013 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on daptomycin (the active ingredients of Daptomycin) and Daptomycin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.