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Daptomycin and Lactic acidosis - a phase IV clinical study of FDA data

Summary:

Lactic acidosis is reported as a side effect among people who take Daptomycin (daptomycin), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Metformin, and have Endocarditis.

The phase IV clinical study analyzes which people have Lactic acidosis when taking Daptomycin. It is created by eHealthMe based on reports of 7,865 people who have side effects when taking Daptomycin from the FDA, and is updated regularly.

What is Daptomycin?

Daptomycin has active ingredients of daptomycin. eHealthMe is studying from 7,879 Daptomycin users. Check the latest studies of Daptomycin.

What is Lactic acidosis?

Lactic acidosis (low ph in body tissues) is found to be associated with 994 drugs and 1,276 conditions by eHealthMe. Check the latest studies of Lactic acidosis.

On Jul, 19, 2026

7,865 people reported to have side effects when taking Daptomycin.
Among them, 99 people (1.26%) have Lactic acidosis.

Could Daptomycin cause Lactic acidosis?

Among these 99 people:

How long have people been on Daptomycin when they have Lactic acidosis? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Lactic acidosis when taking Daptomycin? *

  • female: 86.36 %
  • male: 13.64 %

What is the age of people who have Lactic acidosis when taking Daptomycin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 5.68 %
  • 40-49: 79.55 %
  • 50-59: 2.27 %
  • 60+: 12.5 %

What are other drugs people take besides Daptomycin? *

  1. Metformin: 67 people, 67.68%
  2. Linezolid: 42 people, 42.42%
  3. Metformin Hydrochloride: 8 people, 8.08%
  4. Vancomycin: 6 people, 6.06%
  5. Ondansetron: 5 people, 5.05%
  6. Pantoprazole: 4 people, 4.04%
  7. Lovenox: 3 people, 3.03%
  8. Diflucan: 3 people, 3.03%
  9. Erythromycin: 3 people, 3.03%
  10. Gabapentin: 3 people, 3.03%

What are other side effects people have besides Lactic acidosis? *

  1. Blood Creatine Phosphokinase Increased: 78 people, 78.79%
  2. Septic Shock (shock due to blood infection): 5 people, 5.05%
  3. Drug Level Increased: 4 people, 4.04%
  4. Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 3 people, 3.03%
  5. Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid): 3 people, 3.03%
  6. Hypotension (abnormally low blood pressure): 3 people, 3.03%
  7. Anaemia (lack of blood): 3 people, 3.03%
  8. Consciousness - Decreased: 2 people, 2.02%
  9. Cardiac Arrest: 2 people, 2.02%
  10. Candida Sepsis (candida in blood stream): 2 people, 2.02%

What are the existing conditions these people have? *

  1. Endocarditis (inflammation in heart muscle): 4 people, 4.04%
  2. Enterococcal Infection: 3 people, 3.03%
  3. Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 2 people, 2.02%
  4. Vitamin A Deficiency: 2 people, 2.02%
  5. Hypokalemia (low potassium): 2 people, 2.02%
  6. Hypoglycemia (low blood sugar): 2 people, 2.02%
  7. Haemorrhoids (a swollen vein or group of veins in the region of the anus): 2 people, 2.02%
  8. Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 2 people, 2.02%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 2.02%
  10. Encephalopathy (functioning of the brain is affected by some agent or condition): 2 people, 2.02%

* Approximation only. Some reports may have incomplete information.

Do you take Daptomycin and have Lactic acidosis?

- Check whether Lactic acidosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Daptomycin:

Lactic acidosis treatments and more:

How severe was Lactic acidosis and when was it recovered:

Expand to all the drugs that have ingredients of daptomycin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Daptomycin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lactic acidosis:

Browse all the conditions that are associated with Lactic acidosis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on daptomycin (the active ingredients of Daptomycin) and Daptomycin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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