Daraprim and Fever - a phase IV clinical study of FDA data

Summary:

Fever is reported as a side effect among people who take Daraprim (pyrimethamine), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Sulfadiazine, and have Hiv infection.

The phase IV clinical study analyzes which people have Fever when taking Daraprim. It is created by eHealthMe based on reports of 783 people who have side effects when taking Daraprim from the FDA, and is updated regularly.

What is Daraprim?

Daraprim has active ingredients of pyrimethamine. eHealthMe is studying from 788 Daraprim users. Check the latest studies of Daraprim.

What is Fever?

Fever is found to be associated with 3,495 drugs and 6,198 conditions by eHealthMe. Check the latest studies of Fever.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

783 people reported to have side effects when taking Daraprim.
Among them, 47 people (6.0%) have Fever.

Among these 47 people:

How long have people been on Daraprim when they have Fever? *

What is the gender of people who have Fever when taking Daraprim? *

female: 42.55 %
male: 57.45 %

What is the age of people who have Fever when taking Daraprim? *

What are other drugs people take besides Daraprim? *

What are other side effects people have besides Fever? *

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 10 people, 21.28%
Nausea And Vomiting: 9 people, 19.15%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 8 people, 17.02%
Dizziness: 6 people, 12.77%
Pneumonia: 5 people, 10.64%
Weight Decreased: 5 people, 10.64%
Nausea (feeling of having an urge to vomit): 5 people, 10.64%
Stress And Anxiety: 4 people, 8.51%
Cerebral Toxoplasmosis (parasitic disease of brain caused by the protozoan toxoplasma gondii): 4 people, 8.51%
Leukopenia (less number of white blood cells in blood): 4 people, 8.51%

What are the existing conditions these people have? *

Hiv Infection: 18 people, 38.30%
Toxoplasmosis (a parasitic disease caused by the protozoan toxoplasma gondii): 11 people, 23.40%
Cerebral Toxoplasmosis (parasitic disease of brain caused by the protozoan toxoplasma gondii): 5 people, 10.64%
Vulvovaginal Candidiasis (vulvovaginal infection by fungi): 3 people, 6.38%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 3 people, 6.38%
Breast Cancer: 3 people, 6.38%
Diarrhea: 3 people, 6.38%
Upper Respiratory Tract Infection: 3 people, 6.38%
Acquired Immunodeficiency Syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv)): 3 people, 6.38%
Hiv Test Positive: 2 people, 4.26%

* Approximation only. Some reports may have incomplete information.

Do you take Daraprim and have Fever?

- Check whether Fever is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Daraprim:

Daraprim (788 reports)

Fever treatments and more:

Fever (498,666 reports)

Browse all side effects of Daraprim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fever:

Fever (3,495 drugs)

Browse all the conditions that are associated with Fever:

Fever (6,198 conditions)

Related publications that referenced our studies

Schiller D, Maieron A, Sch?fl R, Donnerer J, "Drug fever due to a single dose of pantoprazole", Pharmacology, 2015 Jan .
Schiller D, Maieron A, Sch?fl R, Donnerer J, "Drug fever due to a single dose of pantoprazole", Pharmacology, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on pyrimethamine (the active ingredients of Daraprim) and Daraprim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.