Dayquil and Chills - a phase IV clinical study of FDA data

Summary:

Chills is reported as a side effect among people who take Dayquil (acetaminophen; dextromethorphan; pseudoephedrine), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Ibuprofen, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Chills when taking Dayquil. It is created by eHealthMe based on reports of 1,538 people who have side effects when taking Dayquil from the FDA, and is updated regularly.

What is Dayquil?

Dayquil has active ingredients of acetaminophen; dextromethorphan; pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 1,815 Dayquil users. Check the latest studies of Dayquil.

What is Chills?

Chills (felling of cold) is found to be associated with 2,572 drugs and 3,471 conditions by eHealthMe. Check the latest studies of Chills.

On Jul, 10, 2026

1,538 people reported to have side effects when taking Dayquil.
Among them, 14 people (0.91%) have Chills.

Among these 14 people:

How long have people been on Dayquil when they have Chills? *

What is the gender of people who have Chills when taking Dayquil? *

female: 76.92 %
male: 23.08 %

What is the age of people who have Chills when taking Dayquil? *

What are other drugs people take besides Dayquil? *

What are other side effects people have besides Chills? *

Nausea (feeling of having an urge to vomit): 6 people, 42.86%
Headache (pain in head): 5 people, 35.71%
Fever: 5 people, 35.71%
Fatigue (feeling of tiredness): 5 people, 35.71%
Dizziness: 4 people, 28.57%
Diarrhea: 3 people, 21.43%
Pain: 3 people, 21.43%
Hyperhidrosis (abnormally increased sweating): 3 people, 21.43%
Cough: 3 people, 21.43%
Oropharyngeal Pain: 3 people, 21.43%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 28.57%
Nasopharyngitis (inflammation of the nasopharynx): 2 people, 14.29%
Small Intestinal Obstruction (blockage in small intestine): 1 person, 7.14%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 7.14%
Primary Immunodeficiency Syndrome: 1 person, 7.14%
Immunodeficiency Disorders: 1 person, 7.14%
Immunodeficiency Common Variable: 1 person, 7.14%
Headache (pain in head): 1 person, 7.14%
Gout (uric acid crystals building up in the body): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Dayquil and have Chills?

- Check whether Chills is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dayquil:

Dayquil (1,815 reports)

Chills treatments and more:

Chills (145,628 reports)

How severe was Chills and when was it recovered:

Chills in Dayquil

Expand to all the drugs that have ingredients of acetaminophen; dextromethorphan; pseudoephedrine:

Chills and drugs with ingredients of acetaminophen; dextromethorphan; pseudoephedrine (7 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Dayquil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Chills:

Chills (2,572 drugs)

Browse all the conditions that are associated with Chills:

Chills (3,471 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; dextromethorphan; pseudoephedrine (the active ingredients of Dayquil) and Dayquil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.