Dayquil and Diarrhea - a phase IV clinical study of FDA data

Summary:

Diarrhea is reported as a side effect among people who take Dayquil (acetaminophen; dextromethorphan; pseudoephedrine), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Paxlovid, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Diarrhea when taking Dayquil. It is created by eHealthMe based on reports of 1,538 people who have side effects when taking Dayquil from the FDA, and is updated regularly.

What is Dayquil?

Dayquil has active ingredients of acetaminophen; dextromethorphan; pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 1,815 Dayquil users. Check the latest studies of Dayquil.

What is Diarrhea?

Diarrhea is found to be associated with 3,730 drugs and 5,750 conditions by eHealthMe. Check the latest studies of Diarrhea.

On Jul, 09, 2026

1,538 people reported to have side effects when taking Dayquil.
Among them, 63 people (4.1%) have Diarrhea.

Among these 63 people:

How long have people been on Dayquil when they have Diarrhea? *

What is the gender of people who have Diarrhea when taking Dayquil? *

female: 62.9 %
male: 37.1 %

What is the age of people who have Diarrhea when taking Dayquil? *

What are other drugs people take besides Dayquil? *

What are other side effects people have besides Diarrhea? *

Nausea (feeling of having an urge to vomit): 11 people, 17.46%
Fatigue (feeling of tiredness): 10 people, 15.87%
Nausea And Vomiting: 9 people, 14.29%
Taste - Impaired: 9 people, 14.29%
Nasopharyngitis (inflammation of the nasopharynx): 9 people, 14.29%
Abdominal Pain Upper: 8 people, 12.70%
Cough: 8 people, 12.70%
Pain: 7 people, 11.11%
Sinusitis (inflammation of sinus): 6 people, 9.52%
Fever: 6 people, 9.52%

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 6 people, 9.52%
Psoriasis (immune-mediated disease that affects the skin): 5 people, 7.94%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 7.94%
Fever: 4 people, 6.35%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 4 people, 6.35%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 6.35%
Pain: 3 people, 4.76%
Acromegaly (body produces too much growth hormone, leading to excess growth of body tissues): 3 people, 4.76%
Cough: 3 people, 4.76%
Depression: 3 people, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Dayquil and have Diarrhea?

- Check whether Diarrhea is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dayquil:

Dayquil (1,815 reports)

Diarrhea treatments and more:

Diarrhea (756,290 reports)

How severe was Diarrhea and when was it recovered:

Diarrhea in Dayquil

Expand to all the drugs that have ingredients of acetaminophen; dextromethorphan; pseudoephedrine:

Diarrhea and drugs with ingredients of acetaminophen; dextromethorphan; pseudoephedrine (145 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Dayquil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Diarrhea:

Diarrhea (3,730 drugs)

Browse all the conditions that are associated with Diarrhea:

Diarrhea (5,750 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; dextromethorphan; pseudoephedrine (the active ingredients of Dayquil) and Dayquil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.