Defitelio and Disease recurrence - a phase IV clinical study of FDA data

Summary:

Disease recurrence is reported as a side effect among people who take Defitelio (defibrotide sodium), especially for people who are female, 10-19 old, have been taking the drug for < 1 month also take Fragmin, and have Venoocclusive liver disease.

The phase IV clinical study analyzes which people have Disease recurrence when taking Defitelio. It is created by eHealthMe based on reports of 4,343 people who have side effects when taking Defitelio from the FDA, and is updated regularly.

What is Defitelio?

Defitelio has active ingredients of defibrotide sodium. eHealthMe is studying from 4,343 Defitelio users. Check the latest studies of Defitelio.

What is Disease recurrence?

Disease recurrence is found to be associated with 1,244 drugs and 1,552 conditions by eHealthMe. Check the latest studies of Disease recurrence.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

4,343 people reported to have side effects when taking Defitelio.
Among them, 14 people (0.32%) have Disease recurrence.

Could Defitelio cause Disease recurrence?

Among these 14 people:

How long have people been on Defitelio when they have Disease recurrence? *

What is the gender of people who have Disease recurrence when taking Defitelio? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Disease recurrence when taking Defitelio? *

What are other drugs people take besides Defitelio? *

What are other side effects people have besides Disease recurrence? *

Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 6 people, 42.86%
Urinary Tract Infection Bacterial: 5 people, 35.71%
Thrombocytopenia (decrease of platelets in blood): 5 people, 35.71%
Acute Graft Versus Host Disease In Liver (acute complication in liver following an allogeneic tissue/blood transplant): 5 people, 35.71%
Shock Haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding): 5 people, 35.71%
Rectal Haemorrhage (bleeding from anus): 5 people, 35.71%
Melaena (the passage of black, tarry stools): 5 people, 35.71%
Catheter Site Haemorrhage (bleeding at catheter site): 2 people, 14.29%
Haemorrhage (bleeding): 2 people, 14.29%
Venoocclusive Liver Disease (small veins in the liver are obstructed): 1 person, 7.14%

What are the existing conditions these people have? *

Venoocclusive Liver Disease (small veins in the liver are obstructed): 8 people, 57.14%
Venoocclusive Disease (small veins in the liver are obstructed): 5 people, 35.71%
Bone Marrow Conditioning Regimen: 5 people, 35.71%
Thrombosis (formation of a blood clot inside a blood vessel): 2 people, 14.29%
High Blood Pressure: 1 person, 7.14%
Fever: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Defitelio and have Disease recurrence?

- Check whether Disease recurrence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Defitelio:

Defitelio (4,343 reports)

Browse all side effects of Defitelio:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Disease recurrence:

Disease recurrence (1,244 drugs)

Browse all the conditions that are associated with Disease recurrence:

Disease recurrence (1,552 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on defibrotide sodium (the active ingredients of Defitelio) and Defitelio (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.