Defitelio and Oedema - a phase IV clinical study of FDA data

Summary:

Oedema is reported as a side effect among people who take Defitelio (defibrotide sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Magnesium, and have Venoocclusive disease.

The phase IV clinical study analyzes which people have Oedema when taking Defitelio. It is created by eHealthMe based on reports of 4,343 people who have side effects when taking Defitelio from the FDA, and is updated regularly.

What is Defitelio?

Defitelio has active ingredients of defibrotide sodium. eHealthMe is studying from 4,343 Defitelio users. Check the latest studies of Defitelio.

What is Oedema?

Oedema (fluid collection in tissue) is found to be associated with 2,194 drugs and 2,311 conditions by eHealthMe. Check the latest studies of Oedema.

On Jul, 20, 2026

4,343 people reported to have side effects when taking Defitelio.
Among them, 12 people (0.28%) have Oedema.

Among these 12 people:

How long have people been on Defitelio when they have Oedema? *

What is the gender of people who have Oedema when taking Defitelio? *

female: 100 %
male: 0.0 %

What is the age of people who have Oedema when taking Defitelio? *

What are other drugs people take besides Defitelio? *

Vitamin K1: 1 person, 8.33%
Valacyclovir Hydrochloride: 1 person, 8.33%
Ursodeoxycholic Acid: 1 person, 8.33%
Ultiva: 1 person, 8.33%
Soliris: 1 person, 8.33%
Noxafil: 1 person, 8.33%
Neoral: 1 person, 8.33%
Mycamine: 1 person, 8.33%
Midazolam: 1 person, 8.33%
Magnesium: 1 person, 8.33%

What are other side effects people have besides Oedema? *

Weight Increased: 3 people, 25.00%
Ascites (accumulation of fluid in the abdominal cavity): 3 people, 25.00%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 2 people, 16.67%
Weight Decreased: 2 people, 16.67%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 2 people, 16.67%
Liver Disorder (liver diseases): 2 people, 16.67%
Pain: 2 people, 16.67%
Pleural Effusion (water on the lungs): 2 people, 16.67%
Pericardial Effusion (fluid around the heart): 2 people, 16.67%
Cardiac Disorder: 1 person, 8.33%

What are the existing conditions these people have? *

Venoocclusive Disease (small veins in the liver are obstructed): 7 people, 58.33%
Venoocclusive Liver Disease (small veins in the liver are obstructed): 1 person, 8.33%
High Blood Pressure: 1 person, 8.33%
Antithrombin Iii Deficiency (rare hereditary disorder that generally comes to light when a patient suffers recurrent venous thrombosis and pulmonary embolism, and repetitive intrauterine fetal death (iufd)): 1 person, 8.33%
Blood Lactate Dehydrogenase Increased: 1 person, 8.33%
Cardiac Failure: 1 person, 8.33%
Fever: 1 person, 8.33%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 8.33%
Haematuria (presence of blood in urine): 1 person, 8.33%
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Defitelio and have Oedema?

- Check whether Oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Defitelio:

Defitelio (4,343 reports)

Oedema treatments and more:

Oedema (78,747 reports)

Browse all side effects of Defitelio:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Oedema:

Oedema (2,194 drugs)

Browse all the conditions that are associated with Oedema:

Oedema (2,311 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on defibrotide sodium (the active ingredients of Defitelio) and Defitelio (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.