1. Home
  2. Analysis
  3. Depakene
  4. Muscle-function-loss

Depakene and Muscle function loss - a phase IV clinical study of FDA data

Summary:

Muscle function loss is reported as a side effect among people who take Depakene (valproic acid), especially for people who are male, 20-29 old, have been taking the drug for 1 - 6 months also take Risperdal, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Muscle function loss when taking Depakene. It is created by eHealthMe based on reports of 14,611 people who have side effects when taking Depakene from the FDA, and is updated regularly.

What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,776 Depakene users. Check the latest studies of Depakene.

What is Muscle function loss?

Muscle function loss is found to be associated with 1,000 drugs and 1,520 conditions by eHealthMe. Check the latest studies of Muscle function loss.

On Jul, 20, 2026

14,611 people reported to have side effects when taking Depakene.
Among them, 35 people (0.24%) have Muscle function loss.

Could Depakene cause Muscle function loss?

Among these 35 people:

How long have people been on Depakene when they have Muscle function loss? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 85.71 %
  • 6 - 12 months: 14.29 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Muscle function loss when taking Depakene? *

  • female: 42.86 %
  • male: 57.14 %

What is the age of people who have Muscle function loss when taking Depakene? *

  • 0-1: 3.45 %
  • 2-9: 0.0 %
  • 10-19: 17.24 %
  • 20-29: 27.59 %
  • 30-39: 10.34 %
  • 40-49: 10.34 %
  • 50-59: 13.79 %
  • 60+: 17.24 %

What are other drugs people take besides Depakene? *

  1. Halcion: 5 people, 14.29%
  2. Paxil: 5 people, 14.29%
  3. Risperdal: 5 people, 14.29%
  4. Tegretol: 4 people, 11.43%
  5. Lamictal: 3 people, 8.57%
  6. Adcirca: 3 people, 8.57%
  7. Amlodipine: 3 people, 8.57%
  8. Opsumit: 3 people, 8.57%
  9. Samsca: 3 people, 8.57%
  10. Axid: 2 people, 5.71%

What are other side effects people have besides Muscle function loss? *

  1. Joint Stiffness: 6 people, 17.14%
  2. Hypoaesthesia Oral (reduced sense of touch or sensation in mouth): 5 people, 14.29%
  3. Gamma-Glutamyltransferase Increased: 5 people, 14.29%
  4. Fatigue (feeling of tiredness): 4 people, 11.43%
  5. Dizziness: 4 people, 11.43%
  6. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 11.43%
  7. Neck Pain: 4 people, 11.43%
  8. Hypokinesia (decreased bodily movement): 4 people, 11.43%
  9. Thrombocytopenia (decrease of platelets in blood): 4 people, 11.43%
  10. Aspartate Aminotransferase Increased: 4 people, 11.43%

What are the existing conditions these people have? *

  1. Cardiac Failure: 3 people, 8.57%
  2. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 8.57%
  3. Glioma (a type of tumour that starts in the brain or spine): 2 people, 5.71%
  4. Petit Mal Epilepsy (absence seizure): 2 people, 5.71%
  5. High Blood Pressure: 2 people, 5.71%
  6. Urinary Tract Infection: 1 person, 2.86%
  7. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 2.86%
  8. Chondrocalcinosis (crystal deposition disease): 1 person, 2.86%
  9. Constipation: 1 person, 2.86%
  10. Depressed Mood: 1 person, 2.86%

* Approximation only. Some reports may have incomplete information.

Do you take Depakene and have Muscle function loss?

- Check whether Muscle function loss is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakene:

Muscle function loss treatments and more:

How severe was Muscle function loss and when was it recovered:

Expand to all the drugs that have ingredients of valproic acid:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Depakene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle function loss:

Browse all the conditions that are associated with Muscle function loss:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Depakene) and Depakene (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.