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Depakene and Psoriasis - a phase IV clinical study of FDA data

Summary:

Psoriasis is reported as a side effect among people who take Depakene (valproic acid), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Lamictal, and have Psoriatic arthropathy.

The phase IV clinical study analyzes which people have Psoriasis when taking Depakene. It is created by eHealthMe based on reports of 14,611 people who have side effects when taking Depakene from the FDA, and is updated regularly.

What is Depakene?

Depakene has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 14,776 Depakene users. Check the latest studies of Depakene.

What is Psoriasis?

Psoriasis (immune-mediated disease that affects the skin) is found to be associated with 1,474 drugs and 1,695 conditions by eHealthMe. Check the latest studies of Psoriasis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

14,611 people reported to have side effects when taking Depakene.
Among them, 26 people (0.18%) have Psoriasis.

Could Depakene cause Psoriasis?

Among these 26 people:

How long have people been on Depakene when they have Psoriasis? *

  • < 1 month: 80 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 20 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Psoriasis when taking Depakene? *

  • female: 36 %
  • male: 64 %

What is the age of people who have Psoriasis when taking Depakene? *

  • 0-1: 0.0 %
  • 2-9: 4.17 %
  • 10-19: 0.0 %
  • 20-29: 20.83 %
  • 30-39: 4.17 %
  • 40-49: 8.33 %
  • 50-59: 45.83 %
  • 60+: 16.67 %

What are other drugs people take besides Depakene? *

  1. Humira: 5 people, 19.23%
  2. Lamictal: 5 people, 19.23%
  3. Lasix: 4 people, 15.38%
  4. Maxalt: 4 people, 15.38%
  5. Allegra: 4 people, 15.38%
  6. Amitiza: 4 people, 15.38%
  7. Azulfidine En-Tabs: 4 people, 15.38%
  8. Cosentyx: 4 people, 15.38%
  9. Voltaren: 4 people, 15.38%
  10. Livostin: 4 people, 15.38%

What are other side effects people have besides Psoriasis? *

  1. Rashes (redness): 6 people, 23.08%
  2. Tremor (trembling or shaking movements in one or more parts of your body): 6 people, 23.08%
  3. Joint Pain: 5 people, 19.23%
  4. Muscle Aches (muscle pain): 4 people, 15.38%
  5. Pain In Extremity: 4 people, 15.38%
  6. Headache (pain in head): 4 people, 15.38%
  7. Protein Total Decreased: 4 people, 15.38%
  8. Dermatosis (a disease of the skin, esp. one that does not cause inflammation): 4 people, 15.38%
  9. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 15.38%
  10. Skin Ulcer: 4 people, 15.38%

What are the existing conditions these people have? *

  1. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 6 people, 23.08%
  2. Insomnia (sleeplessness): 5 people, 19.23%
  3. Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 4 people, 15.38%
  4. Muscle Aches (muscle pain): 4 people, 15.38%
  5. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 4 people, 15.38%
  6. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 15.38%
  7. Constipation: 4 people, 15.38%
  8. Dry Mouth: 4 people, 15.38%
  9. Gastric Cancer (stomach cancer): 4 people, 15.38%
  10. Headache (pain in head): 4 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Depakene and have Psoriasis?

- Check whether Psoriasis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakene:

Psoriasis treatments and more:

How severe was Psoriasis and when was it recovered:

Expand to all the drugs that have ingredients of valproic acid:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Depakene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Psoriasis:

Browse all the conditions that are associated with Psoriasis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Depakene) and Depakene (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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