Depakote er and Death - a phase IV clinical study of FDA data

Summary:

Death is reported as a side effect among people who take Depakote er (divalproex sodium), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Seroquel, and have Affective disorder.

The study is created by eHealthMe based on reports of 5,099 people who have side effects when taking Depakote er from the FDA, and is updated regularly.

What is Depakote er?

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 6,042 Depakote er users. Check the latest studies of Depakote er.

On Jul, 06, 2026

5,099 people reported to have side effects when taking Depakote er.
Among them, 92 people (1.8%) died.

Among these 92 people:

How long have people been on Depakote er when they died? *

What is the gender of people who died when taking Depakote er? *

female: 52.81 %
male: 47.19 %

What is the age of people who died when taking Depakote er? *

What are other drugs people take besides Depakote er? *

What are other side effects people have before they died? *

Exomphalos (weakness of the baby's abdominal wall where the umbilical cord joins it): 6 people, 6.52%
Drug Exposure During Pregnancy: 6 people, 6.52%
Scoliosis (a medical condition in which a person's spine is curved from side to side): 6 people, 6.52%
Stillbirth (a birth of dead foetus): 6 people, 6.52%
Limb Malformation (abnormal birth defect of leg): 6 people, 6.52%
Weakness: 5 people, 5.43%
Cardiac Failure Congestive: 4 people, 4.35%
Insomnia (sleeplessness): 4 people, 4.35%
Drowsiness: 3 people, 3.26%
Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 3 people, 3.26%

What are the existing conditions these people have? *

Affective Disorder (mental disorder): 7 people, 7.61%
Multiple Allergies (allergy to multiple agents): 6 people, 6.52%
Panic Disorder: 6 people, 6.52%
Birth Control: 5 people, 5.43%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 5.43%
Diabetes: 5 people, 5.43%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 4 people, 4.35%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 3 people, 3.26%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 3.26%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 2.17%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakote er:

Depakote er (6,042 reports)

Expand to all the drugs that have ingredients of divalproex sodium:

Death and drugs with ingredients of divalproex sodium (1,225 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Depakote er:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Death:

Death (3,141 drugs)

Browse all the conditions that are associated with Death:

Death (3,686 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Depakote er) and Depakote er (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.