Depakote er and Hypersensitivity - a phase IV clinical study of FDA data

Summary:

Hypersensitivity is reported as a side effect among people who take Depakote er (divalproex sodium), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Depakote, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Hypersensitivity when taking Depakote er. It is created by eHealthMe based on reports of 5,099 people who have side effects when taking Depakote er from the FDA, and is updated regularly.

What is Depakote er?

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 6,042 Depakote er users. Check the latest studies of Depakote er.

What is Hypersensitivity?

Hypersensitivity is found to be associated with 2,750 drugs and 2,915 conditions by eHealthMe. Check the latest studies of Hypersensitivity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

5,099 people reported to have side effects when taking Depakote er.
Among them, 39 people (0.76%) have Hypersensitivity.

Could Depakote er cause Hypersensitivity?

Among these 39 people:

How long have people been on Depakote er when they have Hypersensitivity? *

What is the gender of people who have Hypersensitivity when taking Depakote er? *

female: 67.57 %
male: 32.43 %

What is the age of people who have Hypersensitivity when taking Depakote er? *

What are other drugs people take besides Depakote er? *

What are other side effects people have besides Hypersensitivity? *

Nausea And Vomiting: 11 people, 28.21%
High Blood Pressure: 9 people, 23.08%
Nausea (feeling of having an urge to vomit): 9 people, 23.08%
Rashes (redness): 9 people, 23.08%
Itching: 8 people, 20.51%
Dizziness: 8 people, 20.51%
Abdominal Pain: 8 people, 20.51%
Malaise (a feeling of general discomfort or uneasiness): 8 people, 20.51%
Tremor (trembling or shaking movements in one or more parts of your body): 8 people, 20.51%
Memory Loss: 8 people, 20.51%

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 20.51%
Headache (pain in head): 6 people, 15.38%
High Blood Cholesterol: 6 people, 15.38%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 6 people, 15.38%
Gout (uric acid crystals building up in the body): 5 people, 12.82%
High Blood Pressure: 5 people, 12.82%
Asthma: 5 people, 12.82%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 12.82%
Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 4 people, 10.26%
Stress And Anxiety: 4 people, 10.26%

* Approximation only. Some reports may have incomplete information.

Do you take Depakote er and have Hypersensitivity?

- Check whether Hypersensitivity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakote er:

Depakote er (6,042 reports)

Hypersensitivity treatments and more:

Hypersensitivity (272,618 reports)

Browse all side effects of Depakote er:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypersensitivity:

Hypersensitivity (2,750 drugs)

Browse all the conditions that are associated with Hypersensitivity:

Hypersensitivity (2,915 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Depakote er) and Depakote er (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.