Depakote er and Surgery - a phase IV clinical study of FDA data

Summary:

Surgery is reported as a side effect among people who take Depakote er (divalproex sodium), especially for people who are male, 50-59 old, also take Vimpat, and have Narcolepsy.

The phase IV clinical study analyzes which people have Surgery when taking Depakote er. It is created by eHealthMe based on reports of 5,099 people who have side effects when taking Depakote er from the FDA, and is updated regularly.

What is Depakote er?

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 6,042 Depakote er users. Check the latest studies of Depakote er.

What is Surgery?

Surgery is found to be associated with 1,478 drugs and 1,248 conditions by eHealthMe. Check the latest studies of Surgery.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

5,099 people reported to have side effects when taking Depakote er.
Among them, 23 people (0.45%) have Surgery.

Among these 23 people:

What is the gender of people who have Surgery when taking Depakote er? *

female: 47.62 %
male: 52.38 %

What is the age of people who have Surgery when taking Depakote er? *

What are other drugs people take besides Depakote er? *

Oxycontin: 5 people, 21.74%
Vimpat: 5 people, 21.74%
Lyrica: 4 people, 17.39%
Mobic: 4 people, 17.39%
Xyrem: 4 people, 17.39%
Hydrocodone Bitartrate And Acetaminophen: 4 people, 17.39%
Adderall: 4 people, 17.39%
Norco: 3 people, 13.04%
Soma: 3 people, 13.04%
Keppra: 3 people, 13.04%

What are other side effects people have besides Surgery? *

Stress And Anxiety: 5 people, 21.74%
Aggression: 4 people, 17.39%
Skin - Clammy: 3 people, 13.04%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 3 people, 13.04%
Drug Dependence: 3 people, 13.04%
Drug Abuse: 3 people, 13.04%
Dizziness: 3 people, 13.04%
Pain: 3 people, 13.04%
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 3 people, 13.04%
Weight Decreased: 3 people, 13.04%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 17.39%
Mood Swings (an extreme or rapid change in mood): 3 people, 13.04%
Intervertebral Disc Degeneration (spinal disc degeneration): 3 people, 13.04%
Depression: 3 people, 13.04%
Back Pain: 3 people, 13.04%
Pain: 2 people, 8.70%
Type 2 Diabetes: 1 person, 4.35%
Tardive Dyskinesia (a disorder that involves involuntary movements): 1 person, 4.35%
Suicidal Ideation: 1 person, 4.35%
Stress And Anxiety: 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Depakote er and have Surgery?

- Check whether Surgery is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakote er:

Depakote er (6,042 reports)

Surgery treatments and more:

Surgery (63,811 reports)

Browse all side effects of Depakote er:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Surgery:

Surgery (1,478 drugs)

Browse all the conditions that are associated with Surgery:

Surgery (1,248 conditions)

Related publications that referenced our studies

Briggs P, Hawrylack H, Mooney R, "Inhaled peppermint oil for postop nausea in patients undergoing cardiac surgery", Nursing, 2016 Jul .
Mariappan R, Prasad A, Venkatraghavan L, "An uncommon cause for severe hypophosphataemia after transsphenoidal pituitary surgery", Journal of Neuroanaesthesiology and Critical Care, 2014 May .
Briggs P, Hawrylack H, Mooney R, "Inhaled peppermint oil for postop nausea in patients undergoing cardiac surgery", Nursing, 2016 Jul .
Mariappan R, Prasad A, Venkatraghavan L, "An uncommon cause for severe hypophosphataemia after transsphenoidal pituitary surgery", Journal of Neuroanaesthesiology and Critical Care, 2014 May .

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Depakote er) and Depakote er (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.