Depakote and Encephalitis - a phase IV clinical study of FDA data

Summary:

Encephalitis is reported as a side effect among people who take Depakote (divalproex sodium), especially for people who are male, 40-49 old, also take Onfi, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Encephalitis when taking Depakote. It is created by eHealthMe based on reports of 52,619 people who have side effects when taking Depakote from the FDA, and is updated regularly.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

What is Encephalitis?

Encephalitis (inflammation of the brain) is found to be associated with 655 drugs and 847 conditions by eHealthMe. Check the latest studies of Encephalitis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

52,619 people reported to have side effects when taking Depakote.
Among them, 20 people (0.04%) have Encephalitis.

Among these 20 people:

What is the gender of people who have Encephalitis when taking Depakote? *

female: 45 %
male: 55 %

What is the age of people who have Encephalitis when taking Depakote? *

What are other drugs people take besides Depakote? *

What are other side effects people have besides Encephalitis? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 25.00%
Pneumonia: 4 people, 20.00%
Developmental Delay: 3 people, 15.00%
Meningitis Listeria (a bacterial infection of the membranes covering the brain and spinal cord (meninges)): 3 people, 15.00%
Viral Infection: 3 people, 15.00%
Speech Disorder Developmental: 3 people, 15.00%
Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 3 people, 15.00%
Brain Abscess: 3 people, 15.00%
Dehydration (dryness resulting from the removal of water): 3 people, 15.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 15.00%

What are the existing conditions these people have? *

Primary Immunodeficiency Syndrome: 3 people, 15.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 15.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 10.00%
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 2 people, 10.00%
Muscle Spasms (muscle contraction): 2 people, 10.00%
Combined Immunodeficiency: 2 people, 10.00%
Juvenile Myoclonic Epilepsy (childhood epilepsy occurring early in morning affecting 12 to 18 years): 2 people, 10.00%
Depression: 2 people, 10.00%
Thyroid Diseases: 1 person, 5.00%
Headache (pain in head): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Depakote and have Encephalitis?

- Check whether Encephalitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakote:

Depakote (55,581 reports)

Encephalitis treatments and more:

Encephalitis (9,372 reports)

Browse all side effects of Depakote:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Encephalitis:

Encephalitis (655 drugs)

Browse all the conditions that are associated with Encephalitis:

Encephalitis (847 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Depakote) and Depakote (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.