Depakote and Insulin resistance - a phase IV clinical study of FDA data

Summary:

Insulin resistance is reported as a side effect among people who take Depakote (divalproex sodium), especially for people who are female, 40-49 old, also take Seroquel, and have Depression.

The phase IV clinical study analyzes which people have Insulin resistance when taking Depakote. It is created by eHealthMe based on reports of 52,619 people who have side effects when taking Depakote from the FDA, and is updated regularly.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

What is Insulin resistance?

Insulin resistance is found to be associated with 210 drugs and 416 conditions by eHealthMe. Check the latest studies of Insulin resistance.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

52,619 people reported to have side effects when taking Depakote.
Among them, 28 people (0.05%) have Insulin resistance.

Could Depakote cause Insulin resistance?

Among these 28 people:

What is the gender of people who have Insulin resistance when taking Depakote? *

female: 53.57 %
male: 46.43 %

What is the age of people who have Insulin resistance when taking Depakote? *

What are other drugs people take besides Depakote? *

What are other side effects people have besides Insulin resistance? *

Diabetes: 10 people, 35.71%
Type 2 Diabetes: 9 people, 32.14%
Weight Increased: 7 people, 25.00%
Hyperglycemia (high blood sugar): 7 people, 25.00%
High Blood Pressure: 7 people, 25.00%
High Blood Cholesterol: 7 people, 25.00%
Metabolic Disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues): 7 people, 25.00%
Weight Loss: 6 people, 21.43%
Vision Blurred: 6 people, 21.43%
Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 6 people, 21.43%

What are the existing conditions these people have? *

Depression: 6 people, 21.43%
Stress And Anxiety: 5 people, 17.86%
Sleep Disorder: 4 people, 14.29%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 14.29%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 10.71%
Migraine (headache): 2 people, 7.14%
Psychotic Disorder: 2 people, 7.14%
Poor Quality Sleep: 2 people, 7.14%
Agitation (state of anxiety or nervous excitement): 2 people, 7.14%
Mania (a state of abnormally elevated or irritable mood): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Depakote and have Insulin resistance?

- Check whether Insulin resistance is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakote:

Depakote (55,581 reports)

Browse all side effects of Depakote:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Insulin resistance:

Insulin resistance (210 drugs)

Browse all the conditions that are associated with Insulin resistance:

Insulin resistance (416 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Depakote) and Depakote (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.