Depakote and Nephritis - interstitial - a phase IV clinical study of FDA data

Summary:

Nephritis - interstitial is reported as a side effect among people who take Depakote (divalproex sodium), especially for people who are female, 50-59 old, have been taking the drug for 10+ years also take Nexium, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Nephritis - interstitial when taking Depakote. It is created by eHealthMe based on reports of 52,619 people who have side effects when taking Depakote from the FDA, and is updated regularly.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

What is Nephritis - interstitial?

Nephritis - interstitial (a kidney condition characterized by swelling in between the kidney tubules) is found to be associated with 1,503 drugs and 1,567 conditions by eHealthMe. Check the latest studies of Nephritis - interstitial.

On May, 08, 2026

52,619 people reported to have side effects when taking Depakote.
Among them, 47 people (0.09%) have Nephritis - interstitial.

Could Depakote cause Nephritis - interstitial?

Among these 47 people:

How long have people been on Depakote when they have Nephritis - interstitial? *

What is the gender of people who have Nephritis - interstitial when taking Depakote? *

female: 54.55 %
male: 45.45 %

What is the age of people who have Nephritis - interstitial when taking Depakote? *

What are other drugs people take besides Depakote? *

What are other side effects people have besides Nephritis - interstitial? *

Acute Kidney Failure: 34 people, 72.34%
Chronic Kidney Disease: 28 people, 59.57%
Renal Injury (kidney injury): 10 people, 21.28%
Indigestion: 9 people, 19.15%
Renal Tubular Necrosis (death of kidney tubules): 5 people, 10.64%
Eosinophil Count Increased: 4 people, 8.51%
Nephrogenic Anaemia (anaemia due to kidney disease): 4 people, 8.51%
Type 2 Diabetes: 3 people, 6.38%
Blood Creatinine Increased: 3 people, 6.38%
Type 1 Diabetes: 3 people, 6.38%

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 23 people, 48.94%
Gastric Ph Decreased: 13 people, 27.66%
High Blood Cholesterol: 9 people, 19.15%
Pain: 8 people, 17.02%
Stress And Anxiety: 7 people, 14.89%
Depression: 7 people, 14.89%
Infection: 7 people, 14.89%
Diabetes: 5 people, 10.64%
Affective Disorder (mental disorder): 5 people, 10.64%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 10.64%

* Approximation only. Some reports may have incomplete information.

Do you take Depakote and have Nephritis - interstitial?

- Check whether Nephritis - interstitial is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakote:

Depakote (55,581 reports)

Browse all side effects of Depakote:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nephritis - interstitial:

Nephritis - interstitial (1,503 drugs)

Browse all the conditions that are associated with Nephritis - interstitial:

Nephritis - interstitial (1,567 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Depakote) and Depakote (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.