Depakote and Polysubstance dependence - a phase IV clinical study of FDA data

Summary:

Polysubstance dependence is reported as a side effect among people who take Depakote (divalproex sodium), especially for people who are female, 40-49 old, also take Vistaril, and have Schizophrenia.

The phase IV clinical study analyzes which people have Polysubstance dependence when taking Depakote. It is created by eHealthMe based on reports of 52,619 people who have side effects when taking Depakote from the FDA, and is updated regularly.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

What is Polysubstance dependence?

Polysubstance dependence is found to be associated with 50 drugs and 96 conditions by eHealthMe. Check the latest studies of Polysubstance dependence.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

52,619 people reported to have side effects when taking Depakote.
Among them, 12 people (0.02%) have Polysubstance dependence.

Could Depakote cause Polysubstance dependence?

Among these 12 people:

What is the gender of people who have Polysubstance dependence when taking Depakote? *

female: 83.33 %
male: 16.67 %

What is the age of people who have Polysubstance dependence when taking Depakote? *

What are other drugs people take besides Depakote? *

What are other side effects people have besides Polysubstance dependence? *

Chest Pain: 9 people, 75.00%
Back Pain: 9 people, 75.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 7 people, 58.33%
Fungal Nail Infection: 7 people, 58.33%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 7 people, 58.33%
Xerosis (abnormal dryness of the skin or mucus membranes): 6 people, 50.00%
Sleep Apnea Syndrome: 6 people, 50.00%
Cellulitis (infection under the skin): 6 people, 50.00%
Skin Fissures (a crack in the skin): 6 people, 50.00%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 6 people, 50.00%

What are the existing conditions these people have? *

Stress And Anxiety: 8 people, 66.67%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 8 people, 66.67%
High Blood Pressure: 7 people, 58.33%
Diabetes: 6 people, 50.00%
Postpartum Depression (depression suffered by a mother following childbirth): 6 people, 50.00%
Depression: 3 people, 25.00%
Insomnia (sleeplessness): 3 people, 25.00%
Sleep Disorder: 2 people, 16.67%
Agitation (state of anxiety or nervous excitement): 2 people, 16.67%
Muscle Spasms (muscle contraction): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Depakote and have Polysubstance dependence?

- Check whether Polysubstance dependence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakote:

Depakote (55,581 reports)

Browse all side effects of Depakote:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Polysubstance dependence:

Polysubstance dependence (50 drugs)

Browse all the conditions that are associated with Polysubstance dependence:

Polysubstance dependence (96 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Depakote) and Depakote (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.