Depakote and Small for dates baby - a phase IV clinical study of FDA data

Summary:

Small for dates baby is reported as a side effect among people who take Depakote (divalproex sodium), especially for people who are also take Lamictal, and have Drug exposure during pregnancy.

The phase IV clinical study analyzes which people have Small for dates baby when taking Depakote. It is created by eHealthMe based on reports of 52,619 people who have side effects when taking Depakote from the FDA, and is updated regularly.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

What is Small for dates baby?

Small for dates baby (an unborn baby is growing more slowly and is smaller than most babies are at the same age) is found to be associated with 303 drugs and 430 conditions by eHealthMe. Check the latest studies of Small for dates baby.

On Jul, 31, 2026

52,619 people reported to have side effects when taking Depakote.
Among them, 18 people (0.03%) have Small for dates baby.

Could Depakote cause Small for dates baby?

Among these 18 people:

What are other drugs people take besides Depakote? *

What are other side effects people have besides Small for dates baby? *

Premature Baby: 6 people, 33.33%
Apgar Score Low: 3 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.11%
Foetal Growth Retardation (a baby in the womb fails to grow at the expected rate during the pregnancy): 2 people, 11.11%
Foetal Growth Restriction (poor growth of a baby while in the mother's womb during pregnancy): 2 people, 11.11%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 2 people, 11.11%
Respiratory Distress Syndrome (Rds) In Infants (respiratory disease of newborn babies, especially premature babies, characterized by distressful breathing, cyanosis, and the formation of a glassy membrane over the alveoli of the lungs): 2 people, 11.11%
Musculoskeletal Disorder (disease of the body's muscles, joints, tendons, ligaments and nerves): 2 people, 11.11%
Ventricular Hypertrophy (enlargement of ventricles (lower chambers) in the heart): 1 person, 5.56%
Emotional Disorder: 1 person, 5.56%

What are the existing conditions these people have? *

Drug Exposure During Pregnancy: 4 people, 22.22%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 2 people, 11.11%
Migraine (headache): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Depakote and have Small for dates baby?

- Check whether Small for dates baby is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakote:

Depakote (55,581 reports)

Browse all side effects of Depakote:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Small for dates baby:

Small for dates baby (303 drugs)

Browse all the conditions that are associated with Small for dates baby:

Small for dates baby (430 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Depakote) and Depakote (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.