Depakote and Tendon disorder - a phase IV clinical study of FDA data

Summary:

Tendon disorder is reported as a side effect among people who take Depakote (divalproex sodium), especially for people who are female, 60+ old, also take Lamictal, and have Convulsion.

The phase IV clinical study analyzes which people have Tendon disorder when taking Depakote. It is created by eHealthMe based on reports of 52,619 people who have side effects when taking Depakote from the FDA, and is updated regularly.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

What is Tendon disorder?

Tendon disorder (disease of tendon) is found to be associated with 685 drugs and 726 conditions by eHealthMe. Check the latest studies of Tendon disorder.

On Jul, 15, 2026

52,619 people reported to have side effects when taking Depakote.
Among them, 18 people (0.03%) have Tendon disorder.

Among these 18 people:

What is the gender of people who have Tendon disorder when taking Depakote? *

female: 55.56 %
male: 44.44 %

What is the age of people who have Tendon disorder when taking Depakote? *

What are other drugs people take besides Depakote? *

What are other side effects people have besides Tendon disorder? *

Cough: 5 people, 27.78%
Weakness: 5 people, 27.78%
Gait Disturbance: 5 people, 27.78%
Depression: 4 people, 22.22%
Fatigue (feeling of tiredness): 4 people, 22.22%
Joint Pain: 4 people, 22.22%
Drowsiness: 4 people, 22.22%
Indigestion: 3 people, 16.67%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 3 people, 16.67%
Broken Bone: 3 people, 16.67%

What are the existing conditions these people have? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 16.67%
Nausea (feeling of having an urge to vomit): 2 people, 11.11%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 2 people, 11.11%
Partial Seizures (seizures which affect only a part of the brain at onset): 2 people, 11.11%
Drug Exposure During Pregnancy: 2 people, 11.11%
Migraine (headache): 1 person, 5.56%
Cystitis Interstitial (unknown cause characterized by bladder pain): 1 person, 5.56%
Depression: 1 person, 5.56%
Dyspnea (difficult or laboured breathing): 1 person, 5.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Depakote and have Tendon disorder?

- Check whether Tendon disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakote:

Depakote (55,581 reports)

Tendon disorder treatments and more:

Tendon disorder (8,147 reports)

Browse all side effects of Depakote:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tendon disorder:

Tendon disorder (685 drugs)

Browse all the conditions that are associated with Tendon disorder:

Tendon disorder (726 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Depakote) and Depakote (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.