Depakote and Thrombocythaemia - a phase IV clinical study of FDA data

Summary:

Thrombocythaemia is reported as a side effect among people who take Depakote (divalproex sodium), especially for people who are male, 40-49 old, have been taking the drug for 6 - 12 months also take Clozaril, and have Depression.

The phase IV clinical study analyzes which people have Thrombocythaemia when taking Depakote. It is created by eHealthMe based on reports of 52,619 people who have side effects when taking Depakote from the FDA, and is updated regularly.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

What is Thrombocythaemia?

Thrombocythaemia (an increased number of platelets in the circulating blood) is found to be associated with 211 drugs and 368 conditions by eHealthMe. Check the latest studies of Thrombocythaemia.

On Jul, 06, 2026

52,619 people reported to have side effects when taking Depakote.
Among them, 22 people (0.04%) have Thrombocythaemia.

Among these 22 people:

How long have people been on Depakote when they have Thrombocythaemia? *

What is the gender of people who have Thrombocythaemia when taking Depakote? *

female: 45.45 %
male: 54.55 %

What is the age of people who have Thrombocythaemia when taking Depakote? *

What are other drugs people take besides Depakote? *

What are other side effects people have besides Thrombocythaemia? *

Haematocrit Decreased: 4 people, 18.18%
Pleural Effusion (water on the lungs): 3 people, 13.64%
Fever: 3 people, 13.64%
Anaemia (lack of blood): 3 people, 13.64%
Hyperkalemia (damage to or disease of the kidney): 3 people, 13.64%
Leukocytosis (increased white blood cells): 3 people, 13.64%
Stable Angina (a constant chest pain): 2 people, 9.09%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 2 people, 9.09%
Gallstones (stone formation by bile component): 2 people, 9.09%
Red Cell Aplasia (a type of anaemia affecting the precursors to red blood cells): 2 people, 9.09%

What are the existing conditions these people have? *

Depression: 3 people, 13.64%
High Blood Pressure: 2 people, 9.09%
Stress Urinary Incontinence (leak urine with things like coughing, sneezing or exercise): 1 person, 4.55%
Sleep Disorder: 1 person, 4.55%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 4.55%
Renal Cell Carcinoma (a kidney cancer): 1 person, 4.55%
Mania (a state of abnormally elevated or irritable mood): 1 person, 4.55%
Iron Deficiency: 1 person, 4.55%
Intraocular Pressure Test Abnormal: 1 person, 4.55%
Insomnia (sleeplessness): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Depakote and have Thrombocythaemia?

- Check whether Thrombocythaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakote:

Depakote (55,581 reports)

Browse all side effects of Depakote:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Thrombocythaemia:

Thrombocythaemia (211 drugs)

Browse all the conditions that are associated with Thrombocythaemia:

Thrombocythaemia (368 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Depakote) and Depakote (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.