Depakote and Tooth extraction - a phase IV clinical study of FDA data

Summary:

Tooth extraction is reported as a side effect among people who take Depakote (divalproex sodium), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Vicodin, and have Prostate cancer.

The phase IV clinical study analyzes which people have Tooth extraction when taking Depakote. It is created by eHealthMe based on reports of 52,619 people who have side effects when taking Depakote from the FDA, and is updated regularly.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

What is Tooth extraction?

Tooth extraction is found to be associated with 1,117 drugs and 856 conditions by eHealthMe. Check the latest studies of Tooth extraction.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

52,619 people reported to have side effects when taking Depakote.
Among them, 46 people (0.09%) have Tooth extraction.

Among these 46 people:

How long have people been on Depakote when they have Tooth extraction? *

What is the gender of people who have Tooth extraction when taking Depakote? *

female: 54.35 %
male: 45.65 %

What is the age of people who have Tooth extraction when taking Depakote? *

What are other drugs people take besides Depakote? *

What are other side effects people have besides Tooth extraction? *

Tooth Disorder (tooth disease): 20 people, 43.48%
Fatigue (feeling of tiredness): 19 people, 41.30%
Haemorrhage (bleeding): 19 people, 41.30%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 18 people, 39.13%
Injury: 18 people, 39.13%
Tooth Abscess (pus formation in tooth): 18 people, 39.13%
Bone Disorder: 18 people, 39.13%
Weight Decreased: 17 people, 36.96%
Infection: 16 people, 34.78%
Fever: 16 people, 34.78%

What are the existing conditions these people have? *

Prostate Cancer: 11 people, 23.91%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 19.57%
Pain: 8 people, 17.39%
Oedema (fluid collection in tissue): 7 people, 15.22%
Hypomania (a mild form of mania, marked by elation and hyperactivity): 7 people, 15.22%
Seasonal Affective Disorder (a type of depression that occurs at a certain time of the year, usually in the winter): 5 people, 10.87%
Breast Cancer Metastatic: 2 people, 4.35%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 4.35%
Sleep Disorder: 2 people, 4.35%
Quit Smoking: 2 people, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Depakote and have Tooth extraction?

- Check whether Tooth extraction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Depakote:

Depakote (55,581 reports)

Tooth extraction treatments and more:

Tooth extraction (20,456 reports)

Browse all side effects of Depakote:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tooth extraction:

Tooth extraction (1,117 drugs)

Browse all the conditions that are associated with Tooth extraction:

Tooth extraction (856 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Depakote) and Depakote (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.