Desyrel and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Desyrel (trazodone hydrochloride), especially for people who are male, 60+ old, also take Pantoprazole Sodium, and have Ulcerative colitis.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Desyrel. It is created by eHealthMe based on reports of 6,042 people who have side effects when taking Desyrel from the FDA, and is updated regularly.

What is Desyrel?

Desyrel has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 6,595 Desyrel users. Check the latest studies of Desyrel.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 953 drugs and 1,230 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On May, 06, 2026

6,042 people reported to have side effects when taking Desyrel.
Among them, 13 people (0.22%) have Knee joint replacement.

Could Desyrel cause Knee joint replacement?

Among these 13 people:

What is the gender of people who have Knee joint replacement when taking Desyrel? *

female: 46.15 %
male: 53.85 %

What is the age of people who have Knee joint replacement when taking Desyrel? *

What are other drugs people take besides Desyrel? *

What are other side effects people have besides Knee joint replacement? *

Joint Pain: 7 people, 53.85%
Pain In Extremity: 6 people, 46.15%
Drug Ineffective: 4 people, 30.77%
Back Pain: 3 people, 23.08%
Abdominal Discomfort: 2 people, 15.38%
Peripheral Swelling: 2 people, 15.38%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 2 people, 15.38%
Foot Fracture: 2 people, 15.38%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 15.38%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 15.38%

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 5 people, 38.46%
Stress And Anxiety: 2 people, 15.38%
Nausea (feeling of having an urge to vomit): 2 people, 15.38%
Joint Pain: 2 people, 15.38%
Intervertebral Disc Disorder (spinal disc disorder): 2 people, 15.38%
Back Pain: 2 people, 15.38%
Simple Partial Seizures (seizures which affect only a small region of the brain): 1 person, 7.69%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 7.69%
Ovarian Cancer (cancer of ovary): 1 person, 7.69%
Osteoporosis (bones weak and more likely to break): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Desyrel and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Desyrel:

Desyrel (6,595 reports)

Browse all side effects of Desyrel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (953 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,230 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on trazodone hydrochloride (the active ingredients of Desyrel) and Desyrel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.