Dexedrine and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Dexedrine (dextroamphetamine sulfate), especially for people who are female, 50-59 old, have been taking the drug for 1 - 2 years also take Xyrem, and have Cataplexy.

The phase IV clinical study analyzes which people have Sciatica when taking Dexedrine. It is created by eHealthMe based on reports of 3,977 people who have side effects when taking Dexedrine from the FDA, and is updated regularly.

What is Dexedrine?

Dexedrine has active ingredients of dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 4,735 Dexedrine users. Check the latest studies of Dexedrine.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,137 drugs and 1,437 conditions by eHealthMe. Check the latest studies of Sciatica.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

3,977 people reported to have side effects when taking Dexedrine.
Among them, 12 people (0.3%) have Sciatica.

Among these 12 people:

How long have people been on Dexedrine when they have Sciatica? *

What is the gender of people who have Sciatica when taking Dexedrine? *

female: 100 %
male: 0.0 %

What is the age of people who have Sciatica when taking Dexedrine? *

What are other drugs people take besides Dexedrine? *

Xyrem: 8 people, 66.67%
Vitamin C: 6 people, 50.00%
Synthroid: 6 people, 50.00%
Diclofenac: 5 people, 41.67%
Potassium: 5 people, 41.67%
Vitamin E: 5 people, 41.67%
Lasix: 4 people, 33.33%
Lisinopril And Hydrochlorothiazide: 4 people, 33.33%
Cytomel: 4 people, 33.33%
Neurontin: 4 people, 33.33%

What are other side effects people have besides Sciatica? *

Osteoporosis (bones weak and more likely to break): 6 people, 50.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 50.00%
Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below): 4 people, 33.33%
Rickets (softening of bones): 4 people, 33.33%
Intracranial Aneurysm (bulging, weak area in the wall of a cranial artery): 3 people, 25.00%
Hepatic Steatosis (fatty liver disease): 3 people, 25.00%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 3 people, 25.00%
Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 3 people, 25.00%
Pulmonary Mass: 3 people, 25.00%
Essential Hypertension (primary hypertension): 3 people, 25.00%

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 83.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 33.33%
Wheezing (a high-pitched whistling sound made while you breath): 3 people, 25.00%
Lung Disorder (lung disease): 3 people, 25.00%
High Blood Pressure: 3 people, 25.00%
High Blood Cholesterol: 3 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 25.00%
Dyspnea (difficult or laboured breathing): 3 people, 25.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 16.67%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Dexedrine and have Sciatica?

- Check whether Sciatica is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dexedrine:

Dexedrine (4,735 reports)

Sciatica treatments and more:

Sciatica (28,509 reports)

Browse all side effects of Dexedrine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica:

Sciatica (1,137 drugs)

Browse all the conditions that are associated with Sciatica:

Sciatica (1,437 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dextroamphetamine sulfate (the active ingredients of Dexedrine) and Dexedrine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.