Dexmedetomidine and Hyperpyrexia - a phase IV clinical study of FDA data

Summary:

Hyperpyrexia is reported as a side effect among people who take Dexmedetomidine (dexmedetomidine hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Melatonin, and have Sedation.

The phase IV clinical study analyzes which people have Hyperpyrexia when taking Dexmedetomidine. It is created by eHealthMe based on reports of 4,501 people who have side effects when taking Dexmedetomidine from the FDA, and is updated regularly.

What is Dexmedetomidine?

Dexmedetomidine has active ingredients of dexmedetomidine hydrochloride. eHealthMe is studying from 4,502 Dexmedetomidine users. Check the latest studies of Dexmedetomidine.

What is Hyperpyrexia?

Hyperpyrexia (extremely high fever) is found to be associated with 368 drugs and 530 conditions by eHealthMe. Check the latest studies of Hyperpyrexia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

4,501 people reported to have side effects when taking Dexmedetomidine.
Among them, 16 people (0.36%) have Hyperpyrexia.

Could Dexmedetomidine cause Hyperpyrexia?

Among these 16 people:

How long have people been on Dexmedetomidine when they have Hyperpyrexia? *

What is the gender of people who have Hyperpyrexia when taking Dexmedetomidine? *

female: 37.5 %
male: 62.5 %

What is the age of people who have Hyperpyrexia when taking Dexmedetomidine? *

What are other drugs people take besides Dexmedetomidine? *

What are other side effects people have besides Hyperpyrexia? *

Acute Kidney Failure: 5 people, 31.25%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 3 people, 18.75%
Overdose: 3 people, 18.75%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 2 people, 12.50%
Head Injury: 2 people, 12.50%
Cardiac Failure: 2 people, 12.50%
Serum Ferritin Increased: 1 person, 6.25%
Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 1 person, 6.25%
Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 6.25%
Muscle Rigidity (muscle stiffness): 1 person, 6.25%

What are the existing conditions these people have? *

Sedation: 8 people, 50.00%
Pain: 1 person, 6.25%
Agitation (state of anxiety or nervous excitement): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Dexmedetomidine and have Hyperpyrexia?

- Check whether Hyperpyrexia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dexmedetomidine:

Dexmedetomidine (4,502 reports)

Hyperpyrexia treatments and more:

Hyperpyrexia (4,941 reports)

Browse all side effects of Dexmedetomidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperpyrexia:

Hyperpyrexia (368 drugs)

Browse all the conditions that are associated with Hyperpyrexia:

Hyperpyrexia (530 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dexmedetomidine hydrochloride (the active ingredients of Dexmedetomidine) and Dexmedetomidine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.