Dexmedetomidine and Muscle rigidity - a phase IV clinical study of FDA data

Summary:

Muscle rigidity is reported as a side effect among people who take Dexmedetomidine (dexmedetomidine hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Propofol, and have Sedation.

The phase IV clinical study analyzes which people have Muscle rigidity when taking Dexmedetomidine. It is created by eHealthMe based on reports of 4,501 people who have side effects when taking Dexmedetomidine from the FDA, and is updated regularly.

What is Dexmedetomidine?

Dexmedetomidine has active ingredients of dexmedetomidine hydrochloride. eHealthMe is studying from 4,502 Dexmedetomidine users. Check the latest studies of Dexmedetomidine.

What is Muscle rigidity?

Muscle rigidity (muscle stiffness) is found to be associated with 780 drugs and 1,036 conditions by eHealthMe. Check the latest studies of Muscle rigidity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

4,501 people reported to have side effects when taking Dexmedetomidine.
Among them, 17 people (0.38%) have Muscle rigidity.

Could Dexmedetomidine cause Muscle rigidity?

Among these 17 people:

How long have people been on Dexmedetomidine when they have Muscle rigidity? *

What is the gender of people who have Muscle rigidity when taking Dexmedetomidine? *

female: 60 %
male: 40 %

What is the age of people who have Muscle rigidity when taking Dexmedetomidine? *

What are other drugs people take besides Dexmedetomidine? *

What are other side effects people have besides Muscle rigidity? *

Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 8 people, 47.06%
Fever: 5 people, 29.41%
Agitation (state of anxiety or nervous excitement): 5 people, 29.41%
Catatonia (unresponsive to external stimuli): 4 people, 23.53%
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations): 3 people, 17.65%
Hyperthermia Malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions): 3 people, 17.65%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 3 people, 17.65%
Neuroleptic Malignant Syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 3 people, 17.65%
Urticaria (rash of round, red welts on the skin that itch intensely): 2 people, 11.76%
Disturbance In Attention: 2 people, 11.76%

What are the existing conditions these people have? *

Sedation: 6 people, 35.29%
Bipolar Disorder (mood disorder): 3 people, 17.65%
Agitation (state of anxiety or nervous excitement): 3 people, 17.65%
Neuroleptic Malignant Syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 2 people, 11.76%
General Anaesthesia: 2 people, 11.76%
Delirium (wild excitement): 2 people, 11.76%
Arrhythmias (irregular heartbeat): 2 people, 11.76%
Staphylococcal Infection (an infection with staphylococcus bacteria): 1 person, 5.88%
Pain: 1 person, 5.88%
Mania (a state of abnormally elevated or irritable mood): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Dexmedetomidine and have Muscle rigidity?

- Check whether Muscle rigidity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dexmedetomidine:

Dexmedetomidine (4,502 reports)

Muscle rigidity treatments and more:

Muscle rigidity (16,888 reports)

Browse all side effects of Dexmedetomidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle rigidity:

Muscle rigidity (780 drugs)

Browse all the conditions that are associated with Muscle rigidity:

Muscle rigidity (1,036 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dexmedetomidine hydrochloride (the active ingredients of Dexmedetomidine) and Dexmedetomidine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.