Dexmethylphenidate hydrochloride and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Dexmethylphenidate hydrochloride (dexmethylphenidate hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Tylenol, and have High blood pressure.

The phase IV clinical study analyzes which people have Headache when taking Dexmethylphenidate hydrochloride. It is created by eHealthMe based on reports of 728 people who have side effects when taking Dexmethylphenidate hydrochloride from the FDA, and is updated regularly.

What is Dexmethylphenidate hydrochloride?

Dexmethylphenidate hydrochloride has active ingredients of dexmethylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 774 Dexmethylphenidate hydrochloride users. Check the latest studies of Dexmethylphenidate hydrochloride.

What is Headache?

Headache (pain in head) is found to be associated with 3,754 drugs and 5,775 conditions by eHealthMe. Check the latest studies of Headache.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

728 people reported to have side effects when taking Dexmethylphenidate hydrochloride.
Among them, 70 people (9.62%) have Headache.

Could Dexmethylphenidate hydrochloride cause Headache?

Among these 70 people:

How long have people been on Dexmethylphenidate hydrochloride when they have Headache? *

What is the gender of people who have Headache when taking Dexmethylphenidate hydrochloride? *

female: 80.88 %
male: 19.12 %

What is the age of people who have Headache when taking Dexmethylphenidate hydrochloride? *

What are other drugs people take besides Dexmethylphenidate hydrochloride? *

Tylenol: 39 people, 55.71%
Synthroid: 38 people, 54.29%
Clonidine: 38 people, 54.29%
Vyvanse: 37 people, 52.86%
Amlodipine Besylate: 37 people, 52.86%
Risperidone: 36 people, 51.43%
Sertraline: 34 people, 48.57%
Methylphenidate Hydrochloride: 30 people, 42.86%
Venlafaxine Hydrochloride: 28 people, 40.00%
Atomoxetine Hydrochloride: 28 people, 40.00%

What are other side effects people have besides Headache? *

Nausea (feeling of having an urge to vomit): 46 people, 65.71%
Dizziness: 44 people, 62.86%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 43 people, 61.43%
Drug Ineffective: 42 people, 60.00%
Feeling Abnormal: 41 people, 58.57%
Disturbance In Attention: 41 people, 58.57%
High Blood Pressure: 41 people, 58.57%
Fatigue (feeling of tiredness): 41 people, 58.57%
Drowsiness: 41 people, 58.57%
Hyperhidrosis (abnormally increased sweating): 40 people, 57.14%

What are the existing conditions these people have? *

Oral Herpes (viral infection of mouth): 36 people, 51.43%
High Blood Pressure: 36 people, 51.43%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 4.29%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 2.86%
Drowsiness: 2 people, 2.86%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 2.86%
Tuberous Sclerosis (a rare genetic disease that causes benign tumours to grow in the brain and other organs): 1 person, 1.43%
Stress And Anxiety: 1 person, 1.43%
Pain: 1 person, 1.43%
Learning Disability (difficulty in learning): 1 person, 1.43%

* Approximation only. Some reports may have incomplete information.

Do you take Dexmethylphenidate hydrochloride and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dexmethylphenidate hydrochloride:

Dexmethylphenidate hydrochloride (774 reports)

Headache treatments and more:

Headache (756,642 reports)

How severe was Headache and when was it recovered:

Headache in Dexmethylphenidate hydrochloride

Expand to all the drugs that have ingredients of dexmethylphenidate hydrochloride:

Headache and drugs with ingredients of dexmethylphenidate hydrochloride (265 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Dexmethylphenidate hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,754 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,775 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dexmethylphenidate hydrochloride (the active ingredients of Dexmethylphenidate hydrochloride) and Dexmethylphenidate hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.