Dhc plus and Insomnia - a phase IV clinical study of FDA data

Summary:

Insomnia is reported as a side effect among people who take Dhc plus (acetaminophen; caffeine; dihydrocodeine bitartrate), especially for people who are male, 40-49 old, also take Hydrocodone Bitartrate And Acetaminophen, and have Back pain.

The phase IV clinical study analyzes which people have Insomnia when taking Dhc plus. It is created by eHealthMe based on reports of 1,359 people who have side effects when taking Dhc plus from the FDA, and is updated regularly.

What is Dhc plus?

Dhc plus has active ingredients of acetaminophen; caffeine; dihydrocodeine bitartrate. It is often used in pain. eHealthMe is studying from 1,390 Dhc plus users. Check the latest studies of Dhc plus.

What is Insomnia?

Insomnia (sleeplessness) is found to be associated with 3,116 drugs and 5,173 conditions by eHealthMe. Check the latest studies of Insomnia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 01, 2026

1,359 people reported to have side effects when taking Dhc plus.
Among them, 34 people (2.5%) have Insomnia.

Among these 34 people:

What is the gender of people who have Insomnia when taking Dhc plus? *

female: 32.35 %
male: 67.65 %

What is the age of people who have Insomnia when taking Dhc plus? *

What are other drugs people take besides Dhc plus? *

Hydrocodone Bitartrate And Acetaminophen: 30 people, 88.24%
Hysingla Er: 29 people, 85.29%
Palladone: 25 people, 73.53%
Oxycontin: 17 people, 50.00%
Ms Contin: 11 people, 32.35%
Dilaudid: 10 people, 29.41%
Oxycodone: 9 people, 26.47%
Oxycodone Hydrochloride: 8 people, 23.53%
Morphine Sulfate: 8 people, 23.53%
Tramadol: 7 people, 20.59%

What are other side effects people have besides Insomnia? *

Drug Dependence: 30 people, 88.24%
Stress And Anxiety: 19 people, 55.88%
Depression: 16 people, 47.06%
Overdose: 11 people, 32.35%
Emotional Distress: 8 people, 23.53%
Memory Loss: 8 people, 23.53%
Back Pain: 6 people, 17.65%
Weight Decreased: 6 people, 17.65%
Fatigue (feeling of tiredness): 6 people, 17.65%
Erection Problems: 6 people, 17.65%

What are the existing conditions these people have? *

Back Pain: 3 people, 8.82%
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 2 people, 5.88%
Neck Pain: 1 person, 2.94%
Neck Injury: 1 person, 2.94%
Back Injury: 1 person, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Dhc plus and have Insomnia?

- Check whether Insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Dhc plus:

Dhc plus (1,390 reports)

Insomnia treatments and more:

Insomnia (438,081 reports)

How severe was Insomnia and when was it recovered:

Insomnia in Dhc plus

Expand to all the drugs that have ingredients of acetaminophen; caffeine; dihydrocodeine bitartrate:

Insomnia and drugs with ingredients of acetaminophen; caffeine; dihydrocodeine bitartrate (175 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Dhc plus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Insomnia:

Insomnia (3,116 drugs)

Browse all the conditions that are associated with Insomnia:

Insomnia (5,173 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; caffeine; dihydrocodeine bitartrate (the active ingredients of Dhc plus) and Dhc plus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.