Diclegis and Fatigue aggravated - a phase IV clinical study of FDA data

Summary:

Fatigue aggravated is reported as a side effect among people who take Diclegis (doxylamine succinate; pyridoxine hydrochloride), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Makena, and have Nausea.

The phase IV clinical study analyzes which people have Fatigue aggravated when taking Diclegis. It is created by eHealthMe based on reports of 394 people who have side effects when taking Diclegis from the FDA, and is updated regularly.

What is Diclegis?

Diclegis has active ingredients of doxylamine succinate; pyridoxine hydrochloride. eHealthMe is studying from 404 Diclegis users. Check the latest studies of Diclegis.

What is Fatigue aggravated?

Fatigue aggravated (feeling of tiredness) is found to be associated with 3,161 drugs and 1,117 conditions by eHealthMe. Check the latest studies of Fatigue aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

394 people reported to have side effects when taking Diclegis.
Among them, 12 people (3.05%) have Fatigue aggravated.

Could Diclegis cause Fatigue aggravated?

Among these 12 people:

How long have people been on Diclegis when they have Fatigue aggravated? *

What is the gender of people who have Fatigue aggravated when taking Diclegis? *

female: 90 %
male: 10 %

What is the age of people who have Fatigue aggravated when taking Diclegis? *

What are other drugs people take besides Diclegis? *

What are other side effects people have besides Fatigue aggravated? *

Drowsiness: 4 people, 33.33%
Nausea (feeling of having an urge to vomit): 2 people, 16.67%
Infection: 2 people, 16.67%
Dizziness: 2 people, 16.67%
Drug Ineffective: 2 people, 16.67%
Weight Increased: 1 person, 8.33%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 8.33%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1 person, 8.33%
Burning Sensation: 1 person, 8.33%
Chest Pain: 1 person, 8.33%

What are the existing conditions these people have? *

Vomiting In Pregnancy: 3 people, 25.00%
Premature Delivery: 3 people, 25.00%
Nausea (feeling of having an urge to vomit): 3 people, 25.00%
Immunodeficiency Common Variable: 2 people, 16.67%
Vitamin D Decreased: 1 person, 8.33%
Nausea And Vomiting: 1 person, 8.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 8.33%
Hypophosphatasia (metabolic bone disease): 1 person, 8.33%
Birth Control: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Diclegis and have Fatigue aggravated?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Diclegis:

Diclegis (404 reports)

Fatigue aggravated treatments and more:

Fatigue aggravated (252 reports)

How severe was Fatigue aggravated and when was it recovered:

Fatigue aggravated in Diclegis

Expand to all the drugs that have ingredients of doxylamine succinate; pyridoxine hydrochloride:

Fatigue aggravated and drugs with ingredients of doxylamine succinate; pyridoxine hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Diclegis:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fatigue aggravated:

Fatigue aggravated (3,162 drugs)

Browse all the conditions that are associated with Fatigue aggravated:

Fatigue aggravated (1,117 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on doxylamine succinate; pyridoxine hydrochloride (the active ingredients of Diclegis) and Diclegis (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.