Diclofenac and Ligament rupture - a phase IV clinical study of FDA data

Summary:

Ligament rupture is reported as a side effect among people who take Diclofenac (diclofenac), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Pantoprazole, and have High blood pressure.

The phase IV clinical study analyzes which people have Ligament rupture when taking Diclofenac. It is created by eHealthMe based on reports of 40,952 people who have side effects when taking Diclofenac from the FDA, and is updated regularly.

What is Diclofenac?

Diclofenac has active ingredients of diclofenac. eHealthMe is studying from 41,319 Diclofenac users. Check the latest studies of Diclofenac.

What is Ligament rupture?

Ligament rupture (tear in ligament) is found to be associated with 502 drugs and 550 conditions by eHealthMe. Check the latest studies of Ligament rupture.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

40,952 people reported to have side effects when taking Diclofenac.
Among them, 67 people (0.16%) have Ligament rupture.

Could Diclofenac cause Ligament rupture?

Among these 67 people:

How long have people been on Diclofenac when they have Ligament rupture? *

What is the gender of people who have Ligament rupture when taking Diclofenac? *

female: 69.84 %
male: 30.16 %

What is the age of people who have Ligament rupture when taking Diclofenac? *

What are other drugs people take besides Diclofenac? *

Pantoprazole: 22 people, 32.84%
Amlodipine: 21 people, 31.34%
Metoprolol Succinate: 21 people, 31.34%
Torsemide: 21 people, 31.34%
Valsartan: 21 people, 31.34%
Ramipril: 21 people, 31.34%
Indapamide: 21 people, 31.34%
Pantoprazole Sodium: 20 people, 29.85%
Candesartan Cilexetil: 20 people, 29.85%
Amlodipine Besylate: 20 people, 29.85%

What are other side effects people have besides Ligament rupture? *

Joint Pain: 48 people, 71.64%
Pain: 32 people, 47.76%
Pain In Extremity: 31 people, 46.27%
Headache (pain in head): 30 people, 44.78%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 30 people, 44.78%
Insomnia (sleeplessness): 30 people, 44.78%
Cough: 28 people, 41.79%
The Flu (the flu is caused by an influenza virus): 27 people, 40.30%
Peripheral Swelling: 26 people, 38.81%
Malaise (a feeling of general discomfort or uneasiness): 26 people, 38.81%

What are the existing conditions these people have? *

High Blood Pressure: 22 people, 32.84%
Hyperlipidaemia (presence of excess lipids in the blood): 21 people, 31.34%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 19 people, 28.36%
Oedema Peripheral (superficial swelling): 18 people, 26.87%
Pain: 12 people, 17.91%
High Blood Cholesterol: 11 people, 16.42%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 8.96%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 5 people, 7.46%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 7.46%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 7.46%

* Approximation only. Some reports may have incomplete information.

Do you take Diclofenac and have Ligament rupture?

- Check whether Ligament rupture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Diclofenac:

Diclofenac (41,319 reports)

Browse all side effects of Diclofenac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ligament rupture:

Ligament rupture (502 drugs)

Browse all the conditions that are associated with Ligament rupture:

Ligament rupture (550 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diclofenac (the active ingredients of Diclofenac) and Diclofenac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.