Differin and Agitation - a phase IV clinical study of FDA data

Summary:

Agitation is found among people who take Differin, especially for people who are female, 20-29 old.

The phase IV clinical study analyzes which people take Differin and have Agitation. It is created by eHealthMe based on reports of 5,214 people who have side effects when taking Differin from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 30, 2022

5,214 people reported to have side effects when taking Differin.
Among them, 42 people (0.81%) have Agitation.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,242 Differin users for its effectiveness, alternative drugs and more.

What is Agitation?

Agitation (state of anxiety or nervous excitement) is found to be associated with 3,377 drugs and 3,202 conditions by eHealthMe.

Number of Differin and Agitation reports submitted per year:

Gender of people who have Agitation when taking Differin *:

female: 94.74 %
male: 5.26 %

Age of people who have Agitation when taking Differin *:

Common drugs people take besides Differin *:

Common side effects people have besides Agitation *:

Breathing Difficulty: 29 people, 69.05%
Feeling Abnormal: 28 people, 66.67%
Hypoaesthesia (reduced sense of touch or sensation): 28 people, 66.67%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 26 people, 61.90%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 26 people, 61.90%
Depression: 24 people, 57.14%
Stress And Anxiety: 22 people, 52.38%
Ankle Fracture: 21 people, 50.00%
Weight Decreased: 20 people, 47.62%
Migraine (headache): 20 people, 47.62%

Common conditions people have *:

Osteoporosis (bones weak and more likely to break): 16 people, 38.10%
Affective Disorder (mental disorder): 10 people, 23.81%
Depression: 6 people, 14.29%
Migraine (headache): 5 people, 11.90%
Headache (pain in head): 5 people, 11.90%
Depressive Symptom: 3 people, 7.14%
Seborrhea: 2 people, 4.76%
Androgenetic Alopecia (common form of hair loss): 2 people, 4.76%
Sinus Disorder (disease of sinus): 1 person, 2.38%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 2.38%

* Approximation only. Some reports may have incomplete information.

Do you take Differin and have Agitation?

Check whether Agitation is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .

Related studies

How severe was Agitation and when was it recovered:

Agitation in Differin

Expand to all the drugs that have ingredients of adapalene:

Agitation and drugs with ingredients of adapalene (49 reports)

Alternative drugs to, pros and cons of Differin:

Differin (5,242 reports)

Common Differin side effects:

Dry skin: 1,313 reports
Acne (skin problems that cause pimples): 927 reports
Drug ineffective: 918 reports
Rashes (redness): 868 reports
Itching: 311 reports
Stress and anxiety: 127 reports

Browse all side effects of Differin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Agitation treatments and more:

Agitation (129,194 reports)

COVID vaccines that are related to Agitation:

Common drugs associated with Agitation:

All the drugs that are associated with Agitation:

Agitation (3,377 drugs)

Common conditions associated with Agitation:

Depression: 10,973 reports
Pain: 5,088 reports
Stress and anxiety: 4,945 reports
High blood pressure: 3,933 reports
Schizophrenia: 3,139 reports

All the conditions that are associated with Agitation:

Agitation (3,202 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on adapalene (the active ingredients of Differin) and Differin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.