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Differin and Chapped lips - a phase IV clinical study of FDA data

Summary:

Chapped lips is reported as a side effect among people who take Differin (adapalene), especially for people who are female, 20-29 old, have been taking the drug for < 1 month also take Amnesteem, and have Eczema.

The phase IV clinical study analyzes which people have Chapped lips when taking Differin. It is created by eHealthMe based on reports of 5,708 people who have side effects when taking Differin from the FDA, and is updated regularly.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,740 Differin users. Check the latest studies of Differin.

What is Chapped lips?

Chapped lips (cracking, fissuring, and peeling of the skin f lip) is found to be associated with 464 drugs and 865 conditions by eHealthMe. Check the latest studies of Chapped lips.

On Jan, 11, 2026

5,708 people reported to have side effects when taking Differin.
Among them, 18 people (0.32%) have Chapped lips.

Could Differin cause Chapped lips?

Among these 18 people:

How long have people been on Differin when they have Chapped lips? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Chapped lips when taking Differin? *

  • female: 93.75 %
  • male: 6.25 %

What is the age of people who have Chapped lips when taking Differin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 50.0 %
  • 30-39: 6.25 %
  • 40-49: 43.75 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

What are other drugs people take besides Differin? *

  1. Accutane: 15 people, 83.33%
  2. Amnesteem: 15 people, 83.33%
  3. Doxycycline: 11 people, 61.11%
  4. Nexium: 7 people, 38.89%
  5. Aciphex: 7 people, 38.89%
  6. Advair Diskus 100/50: 7 people, 38.89%
  7. Bextra: 7 people, 38.89%
  8. Cipro: 7 people, 38.89%
  9. Diflucan: 7 people, 38.89%
  10. Elidel: 7 people, 38.89%

What are other side effects people have besides Chapped lips? *

  1. Inflammatory Bowel Disease: 14 people, 77.78%
  2. Sinusitis (inflammation of sinus): 13 people, 72.22%
  3. Dry Skin: 9 people, 50.00%
  4. High Blood Cholesterol: 9 people, 50.00%
  5. Fatigue (feeling of tiredness): 8 people, 44.44%
  6. Hepatic Function Abnormal: 7 people, 38.89%
  7. Proctitis (inflammation of the rectum and anus): 7 people, 38.89%
  8. Aphthous Stomatitis (mouth ulcer): 7 people, 38.89%
  9. Pancreatitis (inflammation of pancreas): 7 people, 38.89%
  10. Autoimmune Hepatitis: 7 people, 38.89%

What are the existing conditions these people have? *

  1. Sinusitis (inflammation of sinus): 7 people, 38.89%
  2. Pain: 7 people, 38.89%
  3. Laryngitis (inflammation of the larynx): 7 people, 38.89%
  4. Irritable Bowel Syndrome: 7 people, 38.89%
  5. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 38.89%
  6. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 7 people, 38.89%
  7. Acne Cystic (skin problems that cause pimples): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Differin and have Chapped lips?

- Check whether Chapped lips is associated with a drug or a condition (FREE)
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Differin:

Chapped lips treatments and more:

How severe was Chapped lips and when was it recovered:

Expand to all the drugs that have ingredients of adapalene:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Differin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Chapped lips:

Browse all the conditions that are associated with Chapped lips:

Drugs similar to Differin and Chapped lips :

How the study uses the data?

The study uses data from the FDA. It is based on adapalene (the active ingredients of Differin) and Differin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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